Catálogo de publicaciones - revistas

<jats:title>Waking up in a trap</jats:title> <jats:p> Cancer patients who have undergone successful treatment can experience relapse of their disease years or even decades later. This is because cancer cells that have disseminated beyond the primary tumor site enter a state of dormancy, where they remain viable but not proliferating. Eventually, by mechanisms that are poorly understood, these clinically undetectable cells “wake up” and form actively growing metastases. Studying mouse models, Albrengues <jats:italic>et al.</jats:italic> found that sustained lung inflammation and the accompanying formation of neutrophil extracellular traps (NETs) could convert dormant cancer cells to aggressive lung metastases (see the Perspective by Aguirre-Ghiso). Awakening of these cells was associated with NET-mediated remodeling of the extracellular matrix and could be prevented by an antibody against the remodeled version of a matrix protein called laminin-111. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aao4227">eaao4227</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6409" page="1314" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aav0191">1314</jats:related-article> </jats:p>

<jats:p> Barbi <jats:italic>et al</jats:italic> . (Reports, 29 June 2018, p. 1459) reported that human mortality rate reached a “plateau” after the age of 105, suggesting there may be no limit to human longevity. We show, using their data, that potential lifespans cannot increase much beyond the current 122 years unless future biomedical advances alter the intrinsic rate of human aging. </jats:p>

<jats:p> Following the Comment of Stewart <jats:italic>et al</jats:italic> ., we repeated our analysis on sequencing runs from The Cancer Genome Atlas (TCGA) using their suggested parameters. We found signs of oxidative damage in all sequence contexts and irrespective of the sequencing date, reaffirming that DNA damage affects mutation-calling pipelines in their ability to accurately identify somatic variations. </jats:p>

<jats:p>Earlier this month, Brazil's National Museum—the oldest, largest, and arguably the most important historical and scientific museum in Latin America—was consumed by fire, stoked by a neglected and degraded infrastructure. It has been a tragic reminder to Brazil and to the rest of the world of how important it is for societies to support the institutions and endeavors that preserve and promote science and culture. This devastating event should serve as a harsh wake-up call for Brazil to bolster, rather than neglect, its scientific enterprise. The general elections next month are an opportunity for Brazil to prioritize science.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Wolf airlift will reboot world's longest running predator-prey study, ended by climate change, inbreeding.</jats:p>

<jats:p>Funding agencies face challenge of sanctioning grantees found guilty without disrupting academic research.</jats:p>

<jats:p>Neutral atoms rise as dark horse qubit candidate.</jats:p>

<jats:p>In mice, disrupting mutant DNA appears to relieve its effects.</jats:p>

<jats:p>New material could reduce cost of cooling buildings by reflecting light and shedding heat.</jats:p>