Catálogo de publicaciones - revistas

<jats:title>Stronger copper through twin power</jats:title> <jats:p> Materials with structural gradients often have unique combinations of properties. Gradient-structured materials are found in nature and can be engineered. Cheng <jats:italic>et al.</jats:italic> made a structural gradient by introducing gradients of crystallographic twins into copper. This strategy creates bundles of dislocations in the crystal interiors, which makes the metal stronger than any of the individual components. This method offers promise for developing high-performance metals. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau1925">eaau1925</jats:related-article> </jats:p>

<jats:title>PAR promotes α-synuclein toxicity</jats:title> <jats:p> How pathologic α-synuclein (α-syn) leads to neurodegeneration in Parkinson's disease (PD) remains poorly understood. Kam <jats:italic>et al.</jats:italic> studied the α-syn preformed fibril (α-syn PFF) model of sporadic PD (see the Perspective by Brundin and Wyse). They found that pathologic α-syn–activated poly(adenosine 5′-diphosphate–ribose) (PAR) polymerase–1 (PARP-1) and inhibition of PARP or knockout of PARP-1 protected mice from pathology. The generation of PAR by α-syn PFF–induced PARP-1 activation converted α-syn PFF to a strain that was 25-fold more toxic, termed PAR–α-syn PFF. An increase of PAR in the cerebrospinal fluid and evidence of PARP activation in the substantia nigra of PD patients indicates that PARP activation contributes to the pathogenesis of PD through parthanatos and conversion of α-syn to a more toxic strain. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat8407">eaat8407</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6414" page="521" related-article-type="in-this-issue" vol="362" xlink:href="10.1126/science.aav3986">521</jats:related-article> </jats:p>

<jats:title>Thalidomide-targeted degradation</jats:title> <jats:p> Thalidomide and its analogs improve the survival of patients with multiple myeloma and other blood cancers. Previous work showed that the drugs bind to the E3 ubiquitin ligase Cereblon, which then targets for degradation two specific zinc finger (ZF) transcription factors with a role in cancer development. Sievers <jats:italic>et al.</jats:italic> found that more ZF proteins than anticipated are destabilized by thalidomide analogs. A proof-of-concept experiment revealed that chemical modifications of thalidomide can lead to selective degradation of specific ZF proteins. The detailed information provided by structural, biochemical, and computational analyses could guide the development of drugs that target ZF transcription factors implicated in human disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat0572">eaat0572</jats:related-article> </jats:p>

<jats:p>For millennia, the Ganges River, holy to Hindus, has provided livelihoods, food, and water for Nepal, India, and Bangladesh. Last month, one of India's leading environmental activists died after a 111-day hunger strike, failing to evoke changes to save India's most revered river (known as Ganga). After years of unrelenting abuse, Ganga is now one of the world's worst polluted rivers. India's Prime Minister Narendra Modi vowed in 2014 to clean Ganga by 2019, but despite increased funding and much lip service, the river is more polluted than before. Mr. Modi needs a new strategy.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Faster, cheaper autonomous systems could aid in resource extraction and science.</jats:p>