Catálogo de publicaciones - revistas

<jats:title>Attack from the front</jats:title> <jats:p> Biomolecular substitution reactions are widely applied to compounds with carbon-halogen bonds. Typically, an incoming reactive group will attack the carbon from behind its bond with the halogen, causing the halogen to depart in the opposite direction. Zhang <jats:italic>et al.</jats:italic> now present an asymmetric catalytic substitution reaction that flips the script with an attack on the halogen from the front. Specifically, nitrogen and sulfur nucleophiles stripped bromine from a variety of carbon centers activated by electron-withdrawing groups. A chiral cationic catalyst then directed the carbon fragment back to form a carbon-sulfur or carbon-nitrogen bond enantioselectively. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6425" page="400" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aau7797">400</jats:related-article> </jats:p>

<jats:title>Embedding palladium ahead of time</jats:title> <jats:p> Palladium-catalyzed cross-coupling is one of the most widely applied reaction classes in pharmaceutical research. The metal is adept at connecting aromatic rings to one another or to nitrogen centers. However, functional complexity can obstruct the reaction, necessitating laborious ligand optimization. Uehling <jats:italic>et al.</jats:italic> mitigated this problem by isolating the stable product of palladium's reaction with a complex aryl halide ahead of time. Subjecting these compounds to downstream coupling reactions substantially improved yields. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6425" page="405" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aac6153">405</jats:related-article> </jats:p>

<jats:title>Diversity in flowering regulation</jats:title> <jats:p> Annual plants flower for one season and then die, whereas perennials can flower repeatedly year after year. Hyun <jats:italic>et al.</jats:italic> explain how different signaling pathways control such variation in flowering. The perennial pathway requires a floral integrator limited to older shoots. The annual pathway, on the other hand, allows a photoperiodic response to incite flowering on young shoots. Solutions to challenging environments may emerge through evolution as the balance between these regulatory systems shifts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6425" page="409" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aau8197">409</jats:related-article> </jats:p>

<jats:title>Inhibitory synapse specificity</jats:title> <jats:p> As neurons build circuits in the developing brain, they select not only what other neurons to connect to but also where on that neuron they will touch base. Working in mice, Favuzzi <jats:italic>et al.</jats:italic> found that gene expression programs that define subsets of interneurons also define where on the postsynaptic partner those interneurons prefer to build a synapse. One class of interneurons prefers to synapse onto the cell body of pyramidal neurons, another class onto the dendrites, and yet another onto the axon initial segment. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6425" page="413" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aau8977">413</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>