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Science

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Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

Top stories: tarantula poaching, a ‘geological Google,’ and fixing health care in Madagascar

Alex Fox

Palabras clave: Multidisciplinary.

Pp. No disponible

NIH letters asking about undisclosed foreign ties rattle U.S. universities

Jeffrey Mervis

Palabras clave: Multidisciplinary.

Pp. No disponible

Erratum for the Research Article “Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy” by R. Cristescu, R. Mogg, M. Ayers, A. Albright, E. Murphy, J. Yearley, X. Sher, X. Q. Liu, H. Lu, M. Nebozhyn, C. Zhang, J. K. Lunceford, A.

Palabras clave: Multidisciplinary.

Pp. No disponible

Pantropical climate interactions

Wenju CaiORCID; Lixin WuORCID; Matthieu LengaigneORCID; Tim Li; Shayne McGregor; Jong-Seong Kug; Jin-Yi YuORCID; Malte F. StueckerORCID; Agus SantosoORCID; Xichen Li; Yoo-Geun HamORCID; Yoshimitsu ChikamotoORCID; Benjamin NgORCID; Michael J. McPhadenORCID; Yan DuORCID; Dietmar DommengetORCID; Fan JiaORCID; Jules B. KajtarORCID; Noel KeenlysideORCID; Xiaopei Lin; Jing-Jia LuoORCID; Marta Martín-ReyORCID; Yohan Ruprich-Robert; Guojian WangORCID; Shang-Ping XieORCID; Yun YangORCID; Sarah M. KangORCID; Jun-Young ChoiORCID; Bolan GanORCID; Geon-Il KimORCID; Chang-Eun KimORCID; Sunyoung Kim; Jeong-Hwan KimORCID; Ping Chang

<jats:title>Tropical interconnections</jats:title> <jats:p> The El Niño–Southern Oscillation, which originates in the tropical Pacific, affects the rest of the world's tropics by perturbing global atmospheric circulation. Less appreciated than this influence is how the tropical Atlantic and Indian Oceans affect the Pacific. Cai <jats:italic>et al.</jats:italic> review what we know about these pantropical interactions, discuss possible ways of improving predictions of current climate variability, and consider how projecting future climate under different anthropogenic forcing scenarios may be improved. They argue that making progress in this field will require sustained global climate observations, climate model improvements, and theoretical advances. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav4236">eaav4236</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

Ying YinORCID; Son C. LeORCID; Allen L. HsuORCID; Mario J. BorgniaORCID; Huanghe YangORCID; Seok-Yong LeeORCID

<jats:title>Cool mechanism for sensing cool</jats:title> <jats:p> In humans, cold is primarily sensed by transient receptor potential melastatin member 8 (TRPM8), a calcium channel. Yin <jats:italic>et al.</jats:italic> present cryo–electron microscopy structures of TRPM8 with cooling agents, membrane lipid phosphatidylinositol-4,5-bisphosphate (PIP2), and calcium. Structural and functional analyses showed that the PIP2 binding site in TRPM8 is completely different from PIP2 sites in other TRP channels. The binding of PIP2 and cooling agents allosterically enhance each other and activate the channel opening. Thus, the activation mechanism of TRPM8 is distinct from that used by other TRP channels. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav9334">eaav9334</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

Revised paleoaltimetry data show low Tibetan Plateau elevation during the Eocene

Svetlana BotsyunORCID; Pierre SepulchreORCID; Yannick Donnadieu; Camille Risi; Alexis LichtORCID; Jeremy K. Caves RugensteinORCID

<jats:title>Ancient height of the Tibetan Plateau</jats:title> <jats:p> The elevation of the Tibetan Plateau has a major impact on climate, affecting the monsoons and regional weather patterns. Although some isotope proxies have suggested a roughly equivalent height for the plateau as far back as the Eocene (∼40 million years ago), other lines of evidence suggest a lower elevation in the distant past. Botsyun <jats:italic>et al.</jats:italic> used a model to show that several previously overlooked factors contribute to the isotopic record from the Eocene (see the Perspective by van Hinsbergen and Boschman). The results harmonize the isotopic record with other proxies and argue for a Tibetan Plateau that was about 1000 meters lower than it is today. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaq1436">eaaq1436</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6430" page="928" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw7705">928</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care

Ha Uk ChungORCID; Bong Hoon KimORCID; Jong Yoon Lee; Jungyup LeeORCID; Zhaoqian XieORCID; Erin M. Ibler; KunHyuck Lee; Anthony BanksORCID; Ji Yoon JeongORCID; Jongwon KimORCID; Christopher Ogle; Dominic GrandeORCID; Yongjoon YuORCID; Hokyung Jang; Pourya AssemORCID; Dennis Ryu; Jean Won KwakORCID; Myeong NamkoongORCID; Jun Bin ParkORCID; Yechan LeeORCID; Do Hoon KimORCID; Arin RyuORCID; Jaeseok Jeong; Kevin YouORCID; Bowen JiORCID; Zhuangjian Liu; Qingze Huo; Xue FengORCID; Yujun Deng; Yeshou Xu; Kyung-In JangORCID; Jeonghyun KimORCID; Yihui ZhangORCID; Roozbeh Ghaffari; Casey M. Rand; Molly Schau; Aaron HamvasORCID; Debra E. Weese-Mayer; Yonggang HuangORCID; Seung Min Lee; Chi Hwan LeeORCID; Naresh R. ShanbhagORCID; Amy S. PallerORCID; Shuai Xu; John A. RogersORCID

<jats:title>Sensitive sensing</jats:title> <jats:p> Neonatal care, particularly for premature babies, is complicated by the infants' fragility and by the need for a large number of tethered sensors to be attached to their tiny bodies. Chung <jats:italic>et al.</jats:italic> developed a pair of sensors that only require water to adhere to the skin and allow for untethered monitoring of key vital signs (see the Perspective by Guinsburg). On-board data processing allowed for efficient wireless near-field communication using standard protocols. The absence of cables makes it easier to handle the infants and allows for skin-to-skin contact between the babies and their parents or caregivers. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau0780">eaau0780</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6430" page="924" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw2085">924</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

Mobilize for peace

Jonathan A. King; Aron Bernstein

<jats:p>Fifty years ago, on 4 March 1969, research and teaching at the Massachusetts Institute of Technology (MIT) came to a halt as students, faculty, and staff held a “research strike” for peace. The strike protested United States involvement in the Vietnam War and MIT's complicity in this engagement through its Instrumentation Laboratory (now the Draper Laboratory), a major contracting lab for the U.S. Department of Defense. The anniversary of this activism by scientists (see the Book Review on page 935) is a reminder that the scientific community must continue to recognize its social responsibilities and promote science as a benefit for all people and for a peaceful world.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 907-907

News at a glance

<jats:p>A roundup of weekly science policy and related news.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 908-910

Collider plans face cloudy prospects

Dennis Normile; Adrian Cho

<jats:p>Physicists brace for decision on Japan's International Linear Collider.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 911-912