Catálogo de publicaciones - revistas

<jats:title>Acoel-regeneration regulatory landscapes</jats:title> <jats:p> Some animals, including some types of worms, can undergo whole-body regeneration and replace virtually any missing cell type. Gehrke <jats:italic>et al.</jats:italic> sequenced and assembled the genome of <jats:italic>Hofstenia miamia</jats:italic> , a regenerative acoel worm species (see the Perspective by Alonge and Schatz). They identified a variable motif corresponding to regulation of the early growth response ( <jats:italic>egr</jats:italic> ) gene that was involved in regeneration. RNA interference experiments and validation in a second species showed that the protein Egr is a pioneer factor that stimulates regeneration. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau6173">eaau6173</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6432" page="1152" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw6258">1152</jats:related-article> </jats:p>

<jats:title>The first fricatives</jats:title> <jats:p> In 1985, the linguist Charles Hockett proposed that the use of teeth and jaws as tools in hunter-gatherer populations makes consonants produced with lower lip and upper teeth (“f” and “v” sounds) hard to produce. He thus conjectured that these sounds were a recent innovation in human language. Blasi <jats:italic>et al.</jats:italic> combined paleoanthropology, speech sciences, historical linguistics, and methods from evolutionary biology to provide evidence for a Neolithic global change in the sound systems of the world's languages. Spoken languages have thus been shaped by changes in the human bite configuration owing to changes in dietary and behavioral practices since the Neolithic. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav3218">eaav3218</jats:related-article> </jats:p>

<jats:title>Tissue macrophages have a split personality</jats:title> <jats:p> Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov <jats:italic>et al.</jats:italic> used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau0964">eaau0964</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6432" page="1154" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw6775">1154</jats:related-article> </jats:p>

<jats:p>Last month, in a conference call held by the U.S. Department of Health and Human Services and National Institutes of Health (NIH), it was revealed that a large focus of President Trump's pledge to fund childhood cancer research will be genomic data sharing. Although the United States has only 5% of the world's pediatric cancer cases, it has disproportionately more resources and access to genomic information compared to low-income countries. We hope that the spotlight on genomic data sharing in the United States will galvanize the world's pediatric cancer community to elevate genomic data sharing to a level where its full potential can finally be realized.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>