Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Editors' Choice
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297-1298
Leadership from behind
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.1-1297
Naked droplets for culturing cells
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.2-1298
Turtles and tortoises in decline
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.3-1298
A core-shell silver cluster
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.4-1298
Careers in STEM start early
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.5-1298
Lysosome repositioning
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.6-1298
Reproducible instability
Caroline Ash; Jesse Smith (eds.)
Palabras clave: Multidisciplinary.
Pp. 1297.7-1298
Structures of human Na v 1.7 channel in complex with auxiliary subunits and animal toxins
Huaizong Shen
; Dongliang Liu; Kun Wu; Jianlin Lei; Nieng Yan
<jats:title>Targeting sodium channels</jats:title> <jats:p> Voltage-gated sodium (Na <jats:sub>v</jats:sub> ) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these channels, making it challenging to develop specific therapeutics. A core α subunit is sufficient for voltage sensing and ion conductance, but function is modulated by β subunits and by natural toxins that can either act as pore blockers or gating modifiers (see the Perspective by Chowdhury and Chanda). Shen <jats:italic>et al.</jats:italic> present the structures of Na <jats:sub>v</jats:sub> 1.7 in complex with both β1 and β2 subunits and with animal toxins. Pan <jats:italic>et al.</jats:italic> present the structure of Na <jats:sub>v</jats:sub> 1.2 bound to β2 and a toxic peptide, the µ-conotoxin KIIIA. The structure shows why KIIIA is specific for Na <jats:sub>v</jats:sub> 1.2. These and other recently determined Na <jats:sub>v</jats:sub> structures provide a framework for targeted drug development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6433" page="1303" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw2493">1303</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6433" page="1309" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw2999">1309</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6433" page="1278" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw8645">1278</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1303-1308
Molecular basis for pore blockade of human Na + channel Na v 1.2 by the μ-conotoxin KIIIA
Xiaojing Pan; Zhangqiang Li; Xiaoshuang Huang; Gaoxingyu Huang; Shuai Gao; Huaizong Shen; Lei Liu; Jianlin Lei; Nieng Yan
<jats:title>Targeting sodium channels</jats:title> <jats:p> Voltage-gated sodium (Na <jats:sub>v</jats:sub> ) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these channels, making it challenging to develop specific therapeutics. A core α subunit is sufficient for voltage sensing and ion conductance, but function is modulated by β subunits and by natural toxins that can either act as pore blockers or gating modifiers (see the Perspective by Chowdhury and Chanda). Shen <jats:italic>et al.</jats:italic> present the structures of Na <jats:sub>v</jats:sub> 1.7 in complex with both β1 and β2 subunits and with animal toxins. Pan <jats:italic>et al.</jats:italic> present the structure of Na <jats:sub>v</jats:sub> 1.2 bound to β2 and a toxic peptide, the µ-conotoxin KIIIA. The structure shows why KIIIA is specific for Na <jats:sub>v</jats:sub> 1.2. These and other recently determined Na <jats:sub>v</jats:sub> structures provide a framework for targeted drug development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6433" page="1303" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw2493">1303</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6433" page="1309" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw2999">1309</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6433" page="1278" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw8645">1278</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1309-1313