Catálogo de publicaciones - revistas

<jats:title>A singular focus on fat</jats:title> <jats:p> Fatty tissue can expand in two ways: through increases in the size of individual adipocytes or through increases in the number of adipocytes. The former process promotes metabolic disease, and the latter protects against it. Merrick <jats:italic>et al.</jats:italic> used single-cell RNA sequencing to define the hierarchy of mesenchymal progenitor cells that give rise to adipose tissue in mice and humans (see the Perspective by Chau and Cawthorn). They found that progenitor cells expressing a protein called DPP4 give rise to two distinct types of preadipocytes in response to different signals. The DPP4 progenitors reside in a fluid-filled network of collagen and elastin fibers surrounding adipose tissue. In principle, therapeutic interventions that increase progenitor cell differentiation into adipocytes could ameliorate metabolic disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav2501">eaav2501</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6438" page="328" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax2967">328</jats:related-article> </jats:p>

<jats:title>Regulating signals at synapses</jats:title> <jats:p> At excitatory synapses in the brain, tetrameric cation channels called AMPA-type glutamate receptors (AMPARs) play a key role in the cellular processes that underlie learning and memory. AMPARs are heterotetramers comprising various compositions of the subunits GluA1 to 4. Herguedas <jats:italic>et al.</jats:italic> used cryo–electron microscopy to determine the structure of the most prevalent form of AMPAR in the hippocampus, the GluA1/2 heteromer in complex with its regulatory subunit TARPγ8. The structure shows the architecture of the complex and provides insight into how conductance is controlled and modulated by auxiliary subunits. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav9011">eaav9011</jats:related-article> </jats:p>

<jats:title>Facilitating “wildness”</jats:title> <jats:p> Humans have encroached upon a majority of Earth's lands. The current extinction crisis is a testament to human impacts on wilderness. If there is any hope of retaining a biodiverse planetary system, we must begin to learn how to coexist with, and leave space for, other species. The practice of “rewilding” has emerged as a method for returning wild lands, and wildness, to landscapes we have altered. Perino <jats:italic>et al.</jats:italic> review this concept and present a framework for implementing it broadly and in a way that considers ongoing human interaction. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav5570">eaav5570</jats:related-article> </jats:p>