Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Scientists want to help restore Notre Dame, hoping to make new discoveries in the process
Tania Rabesandratana
Palabras clave: Multidisciplinary.
Pp. No disponible
Former football pros die at a faster rate than baseball veterans—and the reasons are surprising
Meredith Wadman
Palabras clave: Multidisciplinary.
Pp. No disponible
Germline selection shapes human mitochondrial DNA diversity
Wei Wei
; Salih Tuna; Michael J. Keogh; Katherine R. Smith; Timothy J. Aitman; Phil L. Beales; David L. Bennett; Daniel P. Gale; Maria A. K. Bitner-Glindzicz; Graeme C. Black; Paul Brennan; Perry Elliott; Frances A. Flinter; R. Andres Floto; Henry Houlden; Melita Irving; Ania Koziell; Eamonn R. Maher; Hugh S. Markus; Nicholas W. Morrell; William G. Newman; Irene Roberts; John A. Sayer; Kenneth G. C. Smith; Jenny C. Taylor; Hugh Watkins; Andrew R. Webster; Andrew O. M. Wilkie; Catherine Williamson; Sofie Ashford; Christopher J. Penkett; Kathleen E. Stirrups; Augusto Rendon; Willem H. Ouwehand; John R. Bradley; F. Lucy Raymond; Mark Caulfield; Ernest Turro; Patrick F. Chinnery; Aarnoud P. Huissoon; Abigail Crisp-Hihn; Adam C. Shaw; Adam J. Mead; Adam P. Levine; Adrian J. Thrasher; Agnieszka Bierzynska; Ahamad Hassan; Ajith Kumar; Alba Sanchis-Juan; Alex Richter; Allan Lawrie; Amy J. Frary; Andrea H. Nemeth; Andrea Olschewski; Andreas C. Themistocleous; Andrew C. Browning; Andrew D. Mumford; Andrew M. Schaefer; Andrew Marshall; Andrew O. M. Wilkie; Andrew Peacock; Andrew R. Harper; Andrew R. Webster; Andrew S. C. Rice; Angela Pyle; Ania Koziell; Anna M. Drazyk; Anne M. Kelly; Annette Wagner; Anthony Attwood; Anthony De Soyza; Anthony M. Vandersteen; Anthony T. Moore; Anton Vonk Noordegraaf; Anupama Rao; Archana Herwadkar; Arjan Houweling; Arjune Sen; Augusto Rendon; Austen Worth; Barbara Girerd; Bella Madan; Brian T. Wilson; Carmen Bugarin Diz; Carmen Treacy; Carole Brewer; Carolyn Campbell; Carolyn Millar; Catherine Roughley; Catherine Titterton; Catherine Williamson; Cecilia J. Compton; Cesare Danesino; Chantal Thys; Charaka Hadinnapola; Charu Deshpande; Cheng-Hock Toh; Chris Van Geet; Christian Babbs; Christopher Geoffrey Woods; Christopher J. Penkett; Christopher Watt; Claire Harris; Claire Lentaigne; Claire Palles; Claire Searle; Clarissa Pilkington; Colin Church; Courtney E. French; Crina Samarghitean; D. Mark Layton; Dafydd Gareth Evans; Damian Smedley; Daniel Greene; Daniel Hart; Daniel P. Gale; David G. Kiely; David Gosal; David J. Allsup; David L. Bennett; David Montani; David Parry; David Thomas; Deborah M. Ruddy; Deborah Whitehorn; Detelina Grozeva; Detlef Bockenhauer; Dinakantha Kumararatne; Dragana Josifova; Eamonn R. Maher; Edwin K. S. Wong; Eleanor F. Dewhurst; Eleni Louka; Elizabeth Colby; Elizabeth Ormondroyd; Ellen Thomas; Emilia Swietlik; Emily Staples; Emma Matthews; Emma Woodward; Ernest Turro; Eshika Haque; F. Lucy Raymond; Fengyuan Hu; Fiona Lalloo; Florent Soubrier; Floria Cheng; Frances A. Flinter; Gabor Kovacs; Gavin Arno; Gavin Hudson; Genevieve Sayer; Gerald Carr-White; Gerry Coghlan; Gillian Evans; Graeme C. Black; Grant Hayman; H. Terence Cook; Hana Alachkar; Hana Lango Allen; Hanadi Kazkaz; Hannah Stark; Hanns-Ulrich Marschall; Harm Bogaard; Heather Maxwell; Helen E. Baxendale; Helen L. Hanson; Henning Gall; Henry Houlden; Hilary Longhurst; Hiva Fassihi; Horst Olschewski; Hossein-Ardeschir Ghofrani; Hugh S. Markus; Hugh Watkins; Ian P. Tomlinson; Ilenia Simeoni; Irene Roberts; J. David M. Edgar; J. Simon R. Gibbs; James E. Thaventhiran; James Fox; James S. Ware; James Whitworth; Janine Collins; Jay Suntharalingam; Jennifer Jolley; Jennifer Martin; Jennifer O’Sullivan; Jenny C. Taylor; Jenny Chambers; Jesmeen Maimaris; Jill Clayton-Smith; Joanna Pepke-Zaba; Jodie Graham; John A. Sayer; John-Paul Westwood; John Burn; John Davis; John Wharton; John Taylor; Jonathan Hoffman; Jonathan Stephens; Julian Adlard; Julie von Ziegenweidt; Julie Wessels; Kai Ren Ong; Karen Edwards; Kate Downes; Kate Gibson; Kate Talks; Kate Thomson; Kathelijne Peerlinck; Katherine R. Smith; Katherine Yates; Kathleen E. Stirrups; Kathleen Freson; Katie Snape; Keith Gomez; Keith Sibson; Keith W. Muir; Ken E. S. Poole; Kenneth G. C. Smith; Keren Carss; Kevin J. Marchbank; Kimberly C. Gilmour; Kirsty Harkness; Lara Abulhoul; Laura Scelsi; Leema Robert; Lorena E Lorenzo; Louise Izatt; Lucy Side; Lucy Wedderburn; Luke S. Howard; Lynn Greenhalgh; Manali Chitre; Manju A. Kurian; Marc Humbert; Marc Tischkowitz; Maria A. K. Bitner-Glindzicz; Maria C. Estiu; Marie Erwood; Marie Scully; Mark Caulfield; Mark Gurnell; Mark I. McCarthy; Mark Toshner; Marta Bleda; Marta Vazquez-Lopez; Martin R. Wilkins; Mary Mathias; Matthew Brown; Matthew C. Sims; Matthew Hall; Matthew J. Daniels; Matthew S. Buckland; Matthew Traylor; Matthias Haimel; Maureen Cleary; Mehul Dattani; Mélanie Eyries; Melanie M. Y. Chan; Melanie N. Ekani; Melita Irving; Michael A. Laffan; Michael Gattens; Michael J. Browning; Michael Newnham; Michael Simpson; Michael Wright; Michel Michaelides; Michele Lambert; Moin Saleem; Moira J. Thomas; Monika Mozere; Munaza Ahmed; Naomi Clements Brod; Nathalie Kingston; Neil Shah; Neringa Jurkute; Nichola Cooper; Nicholas W. Morrell; Nicola S. Curry; Nigel Burrows; Nils Koelling; Noemi B. Roy; Olga Shamardina; Olivera Spasic-Boskovic; Omid Sadeghi-Alavijeh; Paolo Gresele; Patrick F. Chinnery; Patrick F. K. Yong; Patrick Yu-Wai-Man; Paul A. Lyons; Paul Aurora; Paul Brennan; Paul Corris; Paul McAlinden; Paula J. Rayner-Matthews; Pavels Gordins; Perry Elliott; Peter H. Dixon; Peter Kelleher; Peter W. Collins; Petros Syrris; Phil L. Beales; Philip Ancliff; Philip Griffiths; Philip Twiss; Ping Yu; Quinten Waisfisz; R. Andres Floto; R. Campbell Tait; Rachel J. Buchan; Rachel Linger; Rashid Kazmi; Ravishankar B. Sargur; Remi Favier; Rhea Y. Y. Tan; Richard Antrobus; Richard Quinton; Richard Scott; Richard Trembath; Rita Horvath; Robert N. Sarkany; Robert Ross-Russell; Robert V. MacKenzie Ross; Robin Condliffe; Roger James; Rosie Hague; Rutendo Mapeta; Ruth Armstrong; Ruth Casey; Sadia Noorani; Salih Tuna; Sally A. Johnson; Samantha Malka; Samya Obaji; Sara Boyce; Sarah Goddard; Sarah J. Rose; Sarah K. Westbury; Sarah Mangles; Sarju Mehta; Scott Hackett; Shahin Moledina; Shamima Rahman; Shehla N. Mohammed; Siddharth Banka; Simon Holden; Simon Pearce; Simon Satchell; Simon Staines; Sinisa Savic; Smita Patel; Sofia Douzgou; Sofia Grigoriadou; Sofia Papadia; Sofie Ashford; Sol Schulman; Soo-Mi Park; Sri V. V. Deevi; Stefan Gräf; Stephen Abbs; Stephen J. Wort; Stephen Jolles; Stephen Marks; Steven Okoli; Stuart Cook; Stuart Meacham; Suellen M. Walker; Susan E. Shapiro; Suthesh Sivapalaratnam; Taco W. Kuijpers; Tadbir Bariana; Tamam Bakchoul; Tamara Everington; Tara Renton; Teofila Bueser; Timothy Dent; Timothy J. Aitman; Tina Biss; Tina Dutt; Tom Fowler; Tom Vale; Tracy Lester; Trevor R. P. Cole; Vijeya Ganesan; W. A. Carrock Sewell; Wei Wei; Wendy N. Erber; Werner Seeger; Wilf Kelsall; Willem H. Ouwehand; William Egner; William G. Newman; William M. Hague; Yvette Wood; ;
<jats:title>Heteroplasmy incidence in mitochondrial DNA</jats:title> <jats:p> In humans, mitochondrial DNA (mtDNA) is predominantly maternally inherited. mtDNA is under selection to prevent heteroplasmy—the transmission of multiple genetic variants into the next generation. Wei <jats:italic>et al.</jats:italic> explored human mtDNA sequences to determine mtDNA genome structure, selection, and transmission. Whole-genome sequencing revealed that about 45% of individuals carry heteroplasmic mtDNA sequences at levels greater than 1% of their total mtDNA. Furthermore, studies of more than 1500 mother-offspring pairs indicated that the female line selected which mtDNA variants were passed on to children. This effect was influenced by the mother's nuclear genetic background. Thus, mtDNA is under selection at specific loci in the human germ line. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau6520">eaau6520</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
Kritika Mohan; George Ueda; Ah Ram Kim; Kevin M. Jude; Jorge A. Fallas; Yu Guo; Maximillian Hafer; Yi Miao; Robert A. Saxton; Jacob Piehler; Vijay G. Sankaran; David Baker; K. Christopher Garcia
<jats:title>Exploring a range of signaling</jats:title> <jats:p> Cytokines are small proteins that bind to the extracellular domains of transmembrane receptors to activate signaling pathways inside the cell. They often act by dimerizing their receptors, and changes in dimer orientation of the extracellular domains can change the signaling output. Mohan <jats:italic>et al.</jats:italic> systematically explored this tuning effect by designing a series of dimer ligands for the erythropoietin receptor in which they varied the distance and angle between monomers. The topology affected the strength of activation and differentially affected different pathways, which raises the potential for exploiting such ligands in medicinal chemistry. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav7532">eaav7532</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
Emma K. Persson; Kenneth Verstraete; Ines Heyndrickx; Elien Gevaert; Helena Aegerter; Jean-Michel Percier; Kim Deswarte; Koen H. G. Verschueren; Ann Dansercoer; Delphine Gras; Pascal Chanez; Claus Bachert; Amanda Gonçalves; Hanne Van Gorp; Hans De Haard; Christophe Blanchetot; Michael Saunders; Hamida Hammad; Savvas N. Savvides; Bart N. Lambrecht
<jats:title>A crystal-clear ingredient for allergy?</jats:title> <jats:p> Charcot-Leyden crystals (CLCs) are formed from the eosinophil granule protein galectin-10 (Gal10) and found in severe eosinophil-associated diseases like asthma and chronic rhinosinusitis. Whether CLCs actively contribute to disease pathogenesis is unknown. Persson <jats:italic>et al.</jats:italic> found that lab-grown Gal10 crystals are biosimilar to CLCs (see the Perspective by Allen and Sutherland). When given to mice, the crystals acted as a type 2 adjuvant, mimicking many of the features of human asthma. In contrast, a Gal10 mutein unable to crystallize had no effect. Antibodies against epitopes crucial for Gal10 autocrystallization could dissolve both in vitro–generated Gal10 crystals and patient-derived CLCs. Furthermore, these anti-Gal10 antibodies reversed the effects of Gal10 crystals in a humanized mouse model of asthma, suggesting a potential therapeutic approach for crystallopathies more broadly. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw4295">eaaw4295</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6442" page="738" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax6175">738</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Brainstem nucleus incertus controls contextual memory formation
András Szőnyi; Katalin E. Sos; Rita Nyilas; Dániel Schlingloff; Andor Domonkos; Virág T. Takács; Balázs Pósfai; Panna Hegedüs; James B. Priestley; Andrew L. Gundlach; Attila I. Gulyás; Viktor Varga; Attila Losonczy; Tamás F. Freund; Gábor Nyiri
<jats:title>What inhibits the inhibitors?</jats:title> <jats:p> In the hippocampus, each memory trace is encoded by a specific subset of pyramidal cells. The other pyramidal cells must be actively excluded from the memory encoding process by inhibition, which is done by selective dendrite-targeting interneurons. Szőnyi <jats:italic>et al.</jats:italic> found that γ-aminobutyric acid–releasing (GABAergic) cells located in a small region in the brain stem called the nucleus incertus project to the hippocampus. The nucleus incertus again is innervated by several regions that respond to salient stimuli. Its GABAergic cells preferentially inhibit the dendrite-targeting interneurons in the hippocampus. The nucleus incertus is thus a central mediator between brain regions that are highly responsive to salient stimuli and the hippocampal circuitry involved in memory formation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw0445">eaaw0445</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
HIV upsurge in China's students
Guanqiao Li; Yan Jiang; Linqi Zhang
<jats:p>Thirty years ago, China experienced its first indigenous HIV/AIDS cases. Since then, HIV has spread from drug users and blood transfusion recipients to the general urban population, mainly through sexual routes. Particularly worrisome is the recent increase of HIV infection among college students, according to the Chinese Center for Disease Control and Prevention (CDC). The number of newly diagnosed college students has seen an annual growth rate ranging from 30 to 50% over the past several years. A proactive approach is required to spread public awareness of this trend and to promote aggressive prevention and treatment measures.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 711-711
News at a glance
<jats:p>A roundup of weekly science policy and related news.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 712-714
A hunt for long-lived particles ramps up
Adrian Cho
<jats:p>The Large Hadron Collider could be making new particles that are hiding in plain sight.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 715-716
Project traces 500 million years of roller-coaster climate
Paul Voosen
<jats:p>Sharp temperature swings pose warning for humanity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 716-717