Catálogo de publicaciones - revistas

<jats:title>Illuminating intestine irradiation</jats:title> <jats:p> High-dose radiation exposure affects multiple body systems, including the blood and the neurovascular system. Radiation can also cause severe intestinal toxicity, known as gastrointestinal syndrome (GIS). Working in mice, Chaves-Pérez <jats:italic>et al.</jats:italic> focused on the mechanisms underlying GIS. The molecular chaperone URI (unconventional prefoldin RPB5 interactor) labeled slow-cycling label-retaining (LR) cells, which are essential for organ regeneration following ionizing radiation. Reduced URI levels rendered LR cells highly proliferative via the activation of the β-catenin/c-MYC axis. Consequently, LR cells became radiosensitive, increasing GIS severity. Thus, URI protects LR cells to promote tissue regeneration in response to high-dose irradiation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaq1165">eaaq1165</jats:related-article> </jats:p>

<jats:title>Fear behavior and the insular cortex</jats:title> <jats:p> Threat learning is important to avoid dangers in the environment. The amygdala is a brain structure involved in the formation of threat memories. How unconditioned stimulus information reaches the amygdala remains unclear. Berret <jats:italic>et al.</jats:italic> found that independent subpopulations of neurons in the insular cortex project either to the lateral or the central amygdala and drive threat learning and fear-associated responses, respectively. Neurons in the posterior insula adapted their response patterns to conditioned stimulus presentation during fear conditioning and maintained this pattern at retrieval. Multisensory integration in the insula thus contributes to the storage and retrieval of threat memories. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw0474">eaaw0474</jats:related-article> </jats:p>

<jats:title>Racing to fertilization</jats:title> <jats:p> Pollen tubes, which carry plant sperm, need to grow from where they land in the flower to where the ovule is. Zhong <jats:italic>et al.</jats:italic> now show how pollen from related plant species race to reach the ovule first. One set of fast-evolving peptide signals is tuned to speed up growth of conspecific pollen tubes. A related set of evolutionarily ancient peptides is tuned to attract all pollen tubes. Thus, fertilization is more likely to happen through conspecific pollen tubes, but a fail-safe system encourages even the laggards to get where they need to go. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau9564">eaau9564</jats:related-article> </jats:p>

<jats:p>The science is clear, students are striking, and publics around the globe are demanding a new level of leadership to tackle the climate crisis before it is too late. Climate extremes are inflicting serious economic losses on nations, and climate-driven issues such as sea-level rise, regional aridification, food shortages, disease spread, and massive biodiversity loss only promise ever-worsening costs. Progress has been too slow since 195 countries signed the 2015 Paris Agreement committing to hold the increase in the global average temperature to well below 2°C above preindustrial levels. To prevent planetary climate disaster, we must all work to speed up bold initiatives that ensure a rapid exit from the era of fossil fuels, and drive carbon dioxide and other greenhouse gas emissions to the atmosphere down to zero in a manner that benefits everyone on the planet, not just a few.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Emory University dismisses neuroscientists, federal agents arrest Los Alamos physicist.</jats:p>