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<jats:p> In an interview with <jats:italic>Science</jats:italic> last week, U.S. Food and Drug Administration Commissioner Margaret Hamburg discussed her plans for the agency and dismissed rumors that she and Deputy Commissioner Joshua Sharfstein would each manage different FDA functions. The interview has been edited for brevity. </jats:p>

<jats:p> <jats:italic>Science</jats:italic> Insider this week reported on what Senate appropriators have called a "serious breach of trust" by staff members of an ambitious children's health study at the National Institutes of Health in withholding the ballooning costs of the project and plans for the cash-strapped University of California to lend $200 million to the state government, among other stories. </jats:p>

<jats:p> A clutch of five letters published online this week shows that <jats:italic>p53</jats:italic> hinders the generation of induced pluripotent stem (iPS) cells. The work suggests ways to control the formation of iPS cells, although that capability will have to be used judiciously because <jats:italic>p53</jats:italic> helps ensure the fitness of generated cells. </jats:p>

<jats:p>Experience has shown that there is more to saving energy than designing better light bulbs and refrigerators. Researchers say it will need a mixture of persuasion, regulation, and taxation.</jats:p>

<jats:p>One watt in every 50 now goes to powering computers, but big savings can still be made by using more-efficient power supplies and automatically putting idling computers into an energy-saving "sleep" mode.</jats:p>

<jats:p>Filmmaker John Johnson is collaborating with the creators of popular video programs on the Web to develop scripts that show people conserving energy and water and considering how their consumption choices might affect the planet.</jats:p>

<jats:p>Current computer-aided design tools are not making it easy for architects to design buildings for energy efficiency. New software is needed.</jats:p>

<jats:p>White light–emitting diodes are still not ready to go head to head with cheaper incandescent bulbs and fluorescents. A new spate of advances, however, suggests that the whitecoats are coming.</jats:p>

<jats:p>Commercial aircraft have become steadily more fuel-efficient by using better engines and reducing the drag and weight of the planes themselves. But efficiency increases beyond that may require a radical change in the shape of the aircraft, which carries enormous risks for manufacturers and airlines.</jats:p>

<jats:p>The single biggest opportunity to increase the "energy productivity" of American industry is to make use of heat that would otherwise be thrown away. One way to do that is via cogeneration, or "combined heat and power," a technique that is more than a century old but newly fashionable.</jats:p>