Catálogo de publicaciones - revistas

<jats:title>Phasing-in quality control in the nucleus</jats:title> <jats:p> The fundamental process of protein quality control in the nucleus is not well understood. The nucleus contains several non–membrane-bound subcompartments forming liquid-like condensates. The largest of these is the nucleolus, the site of ribosome biogenesis. Frottin <jats:italic>et al.</jats:italic> found that metastable nuclear proteins that misfold upon heat stress enter the nucleolus. In the nucleolus, they avoid irreversible aggregation and remain competent for heat shock protein 70–dependent refolding upon recovery from stress. Prolonged stress or the uptake of proteins associated with neurodegenerative diseases prevented this reversibility. Thus, the properties of a phase-separated compartment can assist in protein quality control. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="342" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw9157">342</jats:related-article> </jats:p>

<jats:title>Cryptic alleles make a bridge for adaptation</jats:title> <jats:p> Protein function is generally constrained by selective parameters that can inhibit evolutionary potential. It has thus been difficult to determine how novelties arise. Zheng <jats:italic>et al.</jats:italic> allowed bacterial populations to accumulate mutations and then used directed evolution to evolve green fluorescent protein function from a gene that expressed yellow fluorescent protein (see the Perspective by Lee and Marx). Protein alternatives could evolve in cases where cryptic alleles—selectively neutral or mildly deleterious genetic variants with no apparent phenotypic differences—were present in the population. Thus, cryptic alleles provide an evolutionary bridge between diversity and selection and facilitate the generation of novel adaptations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="347" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax1837">347</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="318" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay2727">318</jats:related-article> </jats:p>

<jats:title>Epigenetics of human embryonic development</jats:title> <jats:p> Substantial epigenetic reprogramming occurs in mammalian early development. Xia <jats:italic>et al.</jats:italic> investigated the reprogramming dynamics of three key histone modifications in human early embryonic development. The reprogramming in humans is highly species-specific and different than that in mice. A globally permissive chromatin state connects parental and zygotic epigenomes during maternal-to-zygotic transition. Inner-cell mass-specific, but not trophectoderm-specific, genes are asymmetrically patterned by a histone mark during early lineage segregation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="353" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw5118">353</jats:related-article> </jats:p>

<jats:title>Two-for-one approach to photoredox</jats:title> <jats:p> In photoredox catalysis, an excited chromophore typically activates a single reactant either by oxidizing or reducing it. Ghosh <jats:italic>et al.</jats:italic> used a semiconductor catalyst to activate two reactants at once by quenching both an excited electron and the residual positive hole (see the Perspective by Swift). As such, two different reactive carbon or halide fragments could be appended to separate sites on an aryl ring. The catalyst also tolerated strong nucleophiles such as cyanide and could be recovered easily and reused. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="360" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw3254">360</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="320" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax8940">320</jats:related-article> </jats:p>