Catálogo de publicaciones - revistas

<jats:title>RNA modification meets immune metabolism</jats:title> <jats:p> <jats:italic>N</jats:italic> <jats:sup>6</jats:sup> -methyladenosine (m <jats:sup>6</jats:sup> A) RNA modification regulates various cellular functions. Liu <jats:italic>et al.</jats:italic> found that host cells impair RNA m <jats:sup>6</jats:sup> A demethylase activity after viral infection, leading to increased m <jats:sup>6</jats:sup> A and reduced stability of α-ketoglutarate dehydrogenase (OGDH) mRNA. As a result, reduced OGDH decreases the generation of itaconate, thereby inhibiting viral replication. The authors explore the function of OGDH and itaconate in viral infection, provide insights into m <jats:sup>6</jats:sup> A RNA modification and metabolic reprogramming in modulating virus-host interaction, and suggest potential therapeutic targets for the control of viral infection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6458" page="1171" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax4468">1171</jats:related-article> </jats:p>

<jats:title>Hazardous delays</jats:title> <jats:p> Neonicotinoids are a widely used group of pesticides that have been shown to have negative impacts on an increasing number of species, most notably pollinators. Eng <jats:italic>et al.</jats:italic> tested how exposure to these compounds influenced the behavior of a migrating songbird. Ingestion of field-realistic levels of neonicotinoid insecticides reduced feeding and accumulation of body mass and fat stores, which led to delayed departure from stopover sites. Such delays can lead to reduced migration survival and decreased reproductive success and therefore have the potential to impose population-level impacts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6458" page="1177" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw9419">1177</jats:related-article> </jats:p>

<jats:title>Role play between rats and humans</jats:title> <jats:p> There is controversy regarding how widespread animal play behavior is and what its evolutionary function might be. Reinhold <jats:italic>et al.</jats:italic> demonstrated that rats can play hide-and-seek with a human. In the “seek” condition, rats learned to look for the hidden humans and kept seeking until they found them. In the “hide” condition, they learned to hide in one of several locations and waited there until being found. In both cases, the rats were rewarded by social interaction with the human. Rats vocalized when seeking and finding and were silent when hiding. Recordings in the medial prefrontal cortex detected neurons that were sensitive to the game structure. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6458" page="1180" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax4705">1180</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>