Catálogo de publicaciones - revistas

<jats:title>A multifaceted future for wind power</jats:title> <jats:p> Modern wind turbines already represent a tightly optimized confluence of materials science and aerodynamic engineering. Veers <jats:italic>et al.</jats:italic> review the challenges and opportunities for further expanding this technology, with an emphasis on the need for interdisciplinary collaboration. They highlight the need to better understand atmospheric physics in the regions where taller turbines will operate as well as the materials constraints associated with the scale-up. The mutual interaction of turbine sites with one another and with the evolving features of the overall electricity grid will furthermore necessitate a systems approach to future development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau2027">eaau2027</jats:related-article> </jats:p>

<jats:title>Commensals rule the MAITrix</jats:title> <jats:p> Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. MAIT cells are absent in germ-free mice, and the mechanisms by which microbiota control MAIT cell development are unknown (see the Perspective by Oh and Unutmaz). Legoux <jats:italic>et al.</jats:italic> show that, in mice, development of MAIT cells within the thymus is governed by the bacterial product 5-(2-oxopropylideneamino)-6- <jats:sc>d</jats:sc> -ribitylaminouracil, which rapidly traffics from the mucosa to the thymus, where it is captured by MR1 and presented to developing MAIT cells. Constantinides <jats:italic>et al.</jats:italic> report that MAIT cell induction only occurs during a limited, early-life window and requires exposure to defined microbes that produce riboflavin derivatives. Continual interactions between MAIT cells and commensals in the skin modulates tissue repair functions. Together, these papers highlight how the microbiota can direct immune cell development and subsequent function at mucosal sites by secreting compounds that act like self-antigens. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6464" page="494" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw2719">494</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax6624">eaax6624</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6464" page="419" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4014">419</jats:related-article> </jats:p>

<jats:title>Plant thirst quenched without water</jats:title> <jats:p> Drought causes many billions of dollars of annual losses to farmers worldwide. Central to a plant's water use efficiency are signaling pathways regulated by the hormone abscisic acid and its receptors. Vaidya <jats:italic>et al.</jats:italic> screened a pool of candidate small molecules and used structure-guided design to optimize the function of an abscisic acid receptor agonist (see the Perspective by Phillips and Sussman). Application of the agonist protected <jats:italic>Arabidopsis</jats:italic> , wheat, and tomato from underwatering. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw8848">eaaw8848</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6464" page="416" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4857">416</jats:related-article> </jats:p>

<jats:title>One world, one health</jats:title> <jats:p>As people increasingly move to cities, their lifestyles profoundly change. Sonnenburg and Sonnenburg review how the shift of recent generations from rural, outdoor environments to urbanized and industrialized settings has profoundly affected our biology and health. The signals of change are seen most strikingly in the reduction of commensal microbial taxa and loss of their metabolic functions. The extirpation of human commensals is a result of bombardment by new chemicals, foodstuffs, sanitation, and medical practices. For most people, sanitation and readily available food have been beneficial, but have we now reached a tipping point? How do we “conserve” our beneficial symbionts and keep the pathogens at bay?</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw9255">eaaw9255</jats:related-article> </jats:p>

<jats:p> This editorial is my last contribution in my role as Editor-in-Chief of the <jats:italic>Science</jats:italic> family of journals. I have had a front-row seat to learning about often astounding research across many disciplines. And I have overseen efforts at three mature journals and helped develop or launch three new ones. As I take stock of this tremendous opportunity, I have been reflecting on the characteristics of privilege, in science and in life. </jats:p>