Catálogo de publicaciones - revistas

<jats:title>Moving modules drive biosynthesis</jats:title> <jats:p> Modular biosynthesis of small molecules—where enzyme units can be swapped in and out of assembly line complexes to produce desired products—is a distant goal in the lab despite a huge diversity of modular systems in nature. Part of the challenge is in understanding how modules interact and hand off intermediates. Reimer <jats:italic>et al.</jats:italic> determined crystal structures of portions of a nonribosomal peptide synthetase, including a full dimodule. Module positioning differed between these structures even when the same intermediate was attached to the enzyme. The authors used small-angle x-ray scattering to confirm that large conformational changes are possible during biosynthesis and handoff between modules. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw4388">eaaw4388</jats:related-article> </jats:p>

<jats:p> Chorev <jats:italic>et al</jats:italic> . (Reports, 16 November 2018, p. 829) describe mass spectrometry on mitochondrial membrane proteins ionized directly from their native environment. However, the assignments made to measured masses are incorrect or inconclusive and lack experimental validation. The proteins are not in their “native” condition: They have been stripped of tightly bound lipids, and the complexes are fragmented or in physiologically irrelevant oligomeric states. </jats:p>

<jats:title>Cultural evolution</jats:title> <jats:p> There is substantial variation in psychological attributes across cultures. Schulz <jats:italic>et al.</jats:italic> examined whether the spread of Catholicism in Europe generated much of this variation (see the Perspective by Gelfand). In particular, they focus on how the Church broke down extended kin-based institutions and encouraged a nuclear family structure. To do this, the authors developed measures of historical Church exposure and kin-based institutions across populations. These measures accounted for individual differences in 20 psychological outcomes collected in prior studies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau5141">eaau5141</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6466" page="686" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz3649">686</jats:related-article> </jats:p>

<jats:title>Growing more and better food</jats:title> <jats:p>Increasing human populations demand more productive agriculture, which in turn relies on crop plants adjusted for high-yield systems. Eshed and Lippman review how genetic tuning of the signaling systems that regulate flowering and plant architecture can be applied to crops. Crops that flower sooner might be adaptable to regions with shorter growing seasons, and compact plant shapes might facilitate agricultural management. The universality of these plant hormone systems facilitates application to a range of crops, from the orphan crop teff to the well-known wheat.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax0025">eaax0025</jats:related-article> </jats:p>