Catálogo de publicaciones - revistas

<jats:title>A fresh look at glutamine targeting</jats:title> <jats:p> Glutamine is essential for tumor growth and has long been an attractive therapeutic target for cancer researchers. Some attempts at blocking glutamine metabolism in cancer patients resulted in toxicity, prompting Leone <jats:italic>et al.</jats:italic> to develop an innovative approach to reduce general side effects. They designed a prodrug form (JHU083) of the glutamine antagonist 6-diazo-5-oxo- <jats:sc>l</jats:sc> -norleucine (DON), which is administered in an inert state but then preferentially activated by enzymes enriched in the tumor microenvironment. JHU083 simultaneously shut down glycolysis and oxidative phosphorylation in mouse cancer cells while enhancing T cell oxidative phosphorylation and anticancer immune responses. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6468" page="1013" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aav2588">1013</jats:related-article> </jats:p>

<jats:title>Common gene yields different structures</jats:title> <jats:p> Nodules form on legume roots to house symbiotic, nitrogen-fixing bacteria. Lateral roots, characteristic of a much broader range of plants, extend to take up nutrients and water from the soil. Soyano <jats:italic>et al.</jats:italic> found common ground in the developmental pathways that build nodules and lateral roots (see the Perspective by Bishopp and Bennett). Evidence from <jats:italic>Lotus japonicus</jats:italic> , a legume that can fix atmospheric nitrogen, shows that the nodule-forming pathway shares components with the lateral root pathway. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6468" page="1021" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aax2153">1021</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6468" page="953" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aay8620">953</jats:related-article> </jats:p>

<jats:title>Sense and respond</jats:title> <jats:p> Many signaling pathways start with cellular proteins sensing and responding to small molecules. Despite advances in protein design, creating a protein-based sense-and-respond system remains challenging. Glasgow <jats:italic>et al.</jats:italic> designed binding sites at the interface of protein heterodimers (see the Perspective by Chica). By fusing each monomer to one half of a split reporter, they linked ligand-driven dimerization to the reporter output. The computational design strategy provides a generalizable approach to create synthetic sensing systems with different outputs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6468" page="1024" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aax8780">1024</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6468" page="952" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz8085">952</jats:related-article> </jats:p>

<jats:title>Mixed signals at tumor margins</jats:title> <jats:p> The Hippo signaling pathway has been implicated in tumor growth, sparking interest in the pathway as a potential therapeutic target. In a study of liver cancer in genetically manipulated mice, Moya <jats:italic>et al.</jats:italic> discovered that the role of this pathway in tumorigenesis is more complex than previously appreciated. They confirmed that activation of the Hippo pathway within tumor cells drives tumor growth; however, they also found that activation of the pathway in adjacent healthy cells has the opposite effect, suppressing tumor growth. Whether tumor cells survive or are eliminated thus appears to depend on competing signals produced by the tumor and surrounding tissue. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6468" page="1029" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw9886">1029</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>