Catálogo de publicaciones - revistas

<jats:title>Stepping to an internal beat</jats:title> <jats:p> What caused the stepwise nature of the rise of molecular oxygen in Earth's atmosphere since it appeared in large quantities more than 2 billion years ago? Alcott <jats:italic>et al.</jats:italic> argue that a set of internal feedbacks involving the global phosphorus, carbon, and oxygen cycles, not individual external forces, could be responsible. Their model, which depends only on a gradual shift from reducing to oxidizing surface conditions over time, produces the same three-step pattern observed in the geological record. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1333" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aax6459">1333</jats:related-article> </jats:p>

<jats:title>Cohesin extrudes DNA loops</jats:title> <jats:p> DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson <jats:italic>et al.</jats:italic> and Kim <jats:italic>et al.</jats:italic> now show that in the presence of the NIPBLMAU2 protein complex, the human cohesin complex can function as a molecular motor that extrudes DNA loops with high speed in vitro. In contrast to how it mediates sister chromatid cohesion, cohesin does not appear to entrap DNA topologically during loop extrusion. The results provide direct evidence for the loop extrusion model of chromatin organization and suggest that genome architecture is highly dynamic. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1338" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz3418">1338</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1345" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4475">1345</jats:related-article> </jats:p>

<jats:title>Cohesin extrudes DNA loops</jats:title> <jats:p> DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson <jats:italic>et al.</jats:italic> and Kim <jats:italic>et al.</jats:italic> now show that in the presence of the NIPBLMAU2 protein complex, the human cohesin complex can function as a molecular motor that extrudes DNA loops with high speed in vitro. In contrast to how it mediates sister chromatid cohesion, cohesin does not appear to entrap DNA topologically during loop extrusion. The results provide direct evidence for the loop extrusion model of chromatin organization and suggest that genome architecture is highly dynamic. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1338" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz3418">1338</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1345" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4475">1345</jats:related-article> </jats:p>

<jats:title>Diamond-based sensors</jats:title> <jats:p> Material properties can change dramatically under pressure. Typically, to achieve high-pressure conditions, researchers place their samples in diamond anvil cells (DACs). However, monitoring the properties of the sample inside a DAC is tricky (see the Perspective by Hamlin and Zhou). Hsieh <jats:italic>et al.</jats:italic> , Lesik <jats:italic>et al.</jats:italic> , and Yip <jats:italic>et al.</jats:italic> developed monitoring techniques based on nitrogen-vacancy (NV) centers in diamond. The NV centers can act as sensors because their energy levels and the associated spectra are sensitive to strain and magnetic fields. This enabled optical readout of a spatially resolved signal. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1349" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw4352">1349</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1359" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw4329">1359</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1355" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw4278">1355</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1312" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4982">1312</jats:related-article> </jats:p>

<jats:title>Diamond-based sensors</jats:title> <jats:p> Material properties can change dramatically under pressure. Typically, to achieve high-pressure conditions, researchers place their samples in diamond anvil cells (DACs). However, monitoring the properties of the sample inside a DAC is tricky (see the Perspective by Hamlin and Zhou). Hsieh <jats:italic>et al.</jats:italic> , Lesik <jats:italic>et al.</jats:italic> , and Yip <jats:italic>et al.</jats:italic> developed monitoring techniques based on nitrogen-vacancy (NV) centers in diamond. The NV centers can act as sensors because their energy levels and the associated spectra are sensitive to strain and magnetic fields. This enabled optical readout of a spatially resolved signal. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1349" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw4352">1349</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1359" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw4329">1359</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1355" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw4278">1355</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6471" page="1312" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4982">1312</jats:related-article> </jats:p>