Catálogo de publicaciones - revistas

<jats:p>Allgeier and Cline suggest that our model overestimates the contributions of cryptobenthic fishes to coral reef functioning. However, their 20-year model ignores the basic biological limits of population growth. If incorporated, cryptobenthic contributions to consumed fish biomass remain high (20 to 70%). Disturbance cycles and uncertainties surrounding the fate of large fishes on decadal scales further demonstrate the important role of cryptobenthic fishes.</jats:p>

<jats:p> Brandl <jats:italic>et al</jats:italic> . (Reports, 21 June 2019, p. 1189) report that cryptobenthic fishes underpin coral reef ecosystem function by contributing ~60% of “consumed fish” biomass and ~20% of production. These results are artifacts of their simulation. Using their data and model, we show that cryptobenthic species contribute less than 4% to fish production, calling into question the extent to which they contribute to the high productivity of coral reefs. </jats:p>

<jats:title>Spying on bacterial signals</jats:title> <jats:p> Many bacteria produce small molecules for monitoring population density and thus regulating their collective behavior, a process termed quorum sensing. Pathogens like <jats:italic>Pseudomonas aeruginosa</jats:italic> , which complicates cystic fibrosis disease, produce different quorum-sensing ligands at different stages of infection. Moura-Alves <jats:italic>et al.</jats:italic> used experiments in human cells, zebrafish, and mice to show that a host organism can eavesdrop on these bacterial conversations. A host sensor responds differentially to bacterial quorum-sensing molecules to activate or repress different response pathways. The ability to “listen in” on bacterial signaling provides the host with the capacity to fine-tune physiologically costly immune responses. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw1629">eaaw1629</jats:related-article> </jats:p>

<jats:title>Biochemical prediction of miRNA targeting</jats:title> <jats:p> MicroRNAs (miRNAs) regulate most human messenger RNAs and play essential roles in diverse developmental and physiological processes. Correctly predicting the function of each miRNA requires a better understanding of miRNA targeting efficacy. McGeary <jats:italic>et al.</jats:italic> measured binding affinities between six miRNAs and synthetic targets, built a biochemical model of miRNA-mediated repression, and expanded it to all miRNAs using a convolutional neural network. This approach offers insights into miRNA targeting and enables more accurate prediction of intracellular miRNA repression efficacy than previous algorithms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav1741">eaav1741</jats:related-article> </jats:p>

<jats:title>A blood cell protein-expression atlas</jats:title> <jats:p> Genome-wide analyses are increasingly providing resources for advances in basic and applied biomedical science. Uhlen <jats:italic>et al.</jats:italic> performed a global expression analysis of human blood cell types and integrated this data with data across all major human tissues and organs in the human protein atlas. This comprehensive compendium allows for classification of all human protein-coding genes with regard to their tissue- and cell-type distribution. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax9198">eaax9198</jats:related-article> </jats:p>

<jats:p>Scientists can often make indirect measurements that tell us about things we can't actually see. For scientists who work on molecules, such as myself, this is especially true: Many of the small and large molecules that dance in my head are objects that I've never actually looked at. But for many outside of science, seeing is believing.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Endangered plants and animals with small ranges and few individuals are at high risk.</jats:p>

<jats:p>Defining "sensitive research" remains a sticking point.</jats:p>