Catálogo de publicaciones - revistas

<jats:title>Finding the fivefold path</jats:title> <jats:p> Crystals formed in nature or synthesized in a lab can have domains with different orientations that are called twins. Having five of these domains is relatively common, but how these fivefold twins form is still a mystery. Song <jats:italic>et al.</jats:italic> combined in situ transmission electron microscope observations with simulations to find two different pathways for forming fivefold twins in gold, platinum, and palladium nanoparticles. This combination provides a key insight into the twin-forming process, which might be exploited for developing nanoparticles suitable for a variety of applications. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="40" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax6511">40</jats:related-article> </jats:p>

<jats:title>Single-cell chemical transcriptomics</jats:title> <jats:p> Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular heterogeneity at the resolution of individual cells. Srivatsan <jats:italic>et al.</jats:italic> now add another layer of information and complexity by combining single-cell transcriptomics with oligo hashing and small molecule screening in a method called sci-Plex. Because screening many chemical compounds requires the ability to profile many cells, and because screens perturb cells in many different ways, the authors demonstrate the effects of 188 compounds in three cancer lines. The sci-Plex method can capture gene expression profiles from thousands of experimental conditions in a single experiment. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="45" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax6234">45</jats:related-article> </jats:p>

<jats:title>An artemisinin resistance mechanism</jats:title> <jats:p> Species of the malaria parasite <jats:italic>Plasmodium</jats:italic> live in red blood cells and possess a highly conserved gene called <jats:italic>kelch13</jats:italic> . Single point mutations in this gene are associated with resistance to the frontline artemisinin drugs. Birnbaum <jats:italic>et al.</jats:italic> found that Kelch13 and associated proteins comprise an endocytic compartment associated with feeding on host erythrocytes (see the Perspective by Marapana and Cowman). Hot targets for artemisinin research also occur in this compartment, including the proteins UBP1, AP-2µ, and the parasite homolog of the endocytosis protein Eps15. Inactivation of Kelch13 compartment proteins revealed that these are required for endocytosis of host hemoglobin. Artemisinins are activated by hemoglobin degradation products, so these mutations render the parasite resistant to these drugs to different extents. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="51" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax4735">51</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="22" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aba0445">22</jats:related-article> </jats:p>

<jats:title>Optically contorting into new dimensions</jats:title> <jats:p> Creating synthetic dimensions has generated interest in many branches of science, ranging from ultracold atomic physics to photonics. The ability to do so provides a versatile platform for realizing effective gauge potentials and novel topological physics that might be difficult or impossible to realize in real systems. Dutt <jats:italic>et al.</jats:italic> show that a structured optical ring cavity can sustain more than one synthetic dimension. Under modulation, coupling the different degrees of freedom within the resonator is used synthesize two additional dimensions. The authors are then able to emulate many complex physical phenomena usually associated with condensed matter systems. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="59" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aaz3071">59</jats:related-article> </jats:p>

<jats:title>Looking for chiral Majoranas</jats:title> <jats:p> Chiral Majorana modes have been predicted to exist in heterostructures consisting of a quantum anomalous Hall insulator and a superconductor. Kayyalha <jats:italic>et al.</jats:italic> fabricated more than 30 such samples and used transport measurements to look for signatures of the Majorana modes. The data indicated that the transport signatures previously thought to be associated with Majorana physics could, in their samples, be explained using a more mundane mechanism. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="64" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax6361">64</jats:related-article> </jats:p>

<jats:title>Manipulating the gap</jats:title> <jats:p> Cuprate superconductors typically have a large amount of spatial inhomogeneity, partly stemming from the inhomogeneity of the chemical doping process. In particular, the size of the spectroscopic gap can vary widely across a single sample. Massee <jats:italic>et al.</jats:italic> used the tip of a scanning tunneling microscope to manipulate atoms on the surface of a member of the Bi <jats:sub>2</jats:sub> Sr <jats:sub>2</jats:sub> CaCu <jats:sub>2</jats:sub> O <jats:sub>8+x</jats:sub> cuprate family. Moving bismuth atoms up or down caused adjacent atoms to shift laterally, leading to reversible local changes in the size of the gap. It is expected that the technique can be used to probe the influence of the local lattice on the electronic states of other correlated materials. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6473" page="68" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aaw7964">68</jats:related-article> </jats:p>