Catálogo de publicaciones - revistas

<jats:title>Visualizing whole cells at many scales</jats:title> <jats:p> Cells need to compartmentalize thousands of distinct proteins, but the nanoscale spatial relationship of many proteins to overall intracellular ultrastructure remains poorly understood. Correlated light and electron microscopy approaches can help. Hoffman <jats:italic>et al.</jats:italic> combined cryogenic super-resolution fluorescence microscopy and focused ion beam–milling scanning electron microscopy to visualize protein-ultrastructure relationships in three dimensions across whole cells. The fusion of the two imaging modalities enabled identification and three-dimensional segmentation of morphologically complex structures within the crowded intracellular environment. The researchers observed unexpected relationships within a variety of cell types, including a web-like protein adhesion network between juxtaposed cerebellar granule neurons. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaz5357">eaaz5357</jats:related-article> </jats:p>

<jats:title>An overview of an exotic type of liquid</jats:title> <jats:p> Materials with interacting quantum spins that nevertheless do not order magnetically down to the lowest temperatures are candidates for a materials class called quantum spin liquids (QSLs). QSLs are characterized by long-range quantum entanglement and are tricky to study theoretically; an even more difficult task is to experimentally prove that a material is a QSL. Broholm <jats:italic>et al.</jats:italic> take a broad view of the state of the field and comment on the upcoming challenges. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay0668">eaay0668</jats:related-article> </jats:p>

<jats:title>A VISTA on naïve T cell fate</jats:title> <jats:p> T cell quiescence and tolerance restrain the immune system from becoming overactive and attacking healthy tissue. Negative checkpoint regulators normally limit T cell responses to help safeguard against conditions such as autoimmunity. ElTanbouly <jats:italic>et al.</jats:italic> report that the checkpoint regulator VISTA (V-type immunoglobulin domain-containing suppressor of T cell activation) restricts early stages of T cell activation by shaping the inherent heterogeneity of the naïve CD4 <jats:sup>+</jats:sup> T cell compartment to one that is more uniformly quiescent and silent (see the Perspective by Brown and Rudensky). Therapeutic targeting of VISTA using an agonistic antibody in mice curbed the development of graft-versus-host disease and promoted the death of naïve T cells abnormally activated by self-antigen. VISTA thus represents a distinctive immunoregulatory molecule that controls naïve T cell function by maintaining quiescence and peripheral tolerance. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay0524">eaay0524</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6475" page="247" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aaz7741">247</jats:related-article> </jats:p>

<jats:p>A century ago, the 18th Amendment to the United States Constitution went into effect, banning the “manufacture, sale, or transportation of intoxicating liquors.” Fourteen years after its ratification, the 18th Amendment was repealed by the 21st Amendment. What did Prohibition teach us about banning hazardous products like alcohol, tobacco, or e-cigarettes?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Pneumonia outbreak in Wuhan appears to subside, but the virus could re-emerge.</jats:p>