Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu
; Xiaoyang Dou; Chuanyuan Chen; Chuan Chen; Chang Liu; Meng Michelle Xu; Siqi Zhao; Bin Shen; Yawei Gao; Dali Han; Chuan He
<jats:title>A new layer of transcriptional control</jats:title> <jats:p> <jats:italic>N</jats:italic> <jats:sup>6</jats:sup> -methyladenosine (m <jats:sup>6</jats:sup> A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu <jats:italic>et al.</jats:italic> now show that m <jats:sup>6</jats:sup> A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m <jats:sup>6</jats:sup> A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m <jats:sup>6</jats:sup> A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6477" page="580" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aay6018">580</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 580-586
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia
Hannah J. Uckelmann; Stephanie M. Kim; Eric M. Wong; Charles Hatton; Hugh Giovinazzo; Jayant Y. Gadrey; Andrei V. Krivtsov; Frank G. Rücker; Konstanze Döhner; Gerard M. McGeehan; Ross L. Levine; Lars Bullinger; George S. Vassiliou; Scott A. Armstrong
<jats:title>Taking preventive measures</jats:title> <jats:p> Recent technological advances have made it possible to detect, in healthy individuals, premalignant blood cells that are likely to progress to hematologic cancer. These advances in early detection have fueled interest in “cancer interception,” the idea that drugs designed to treat advanced cancer might also be useful for cancer prevention. Uckelmann <jats:italic>et al.</jats:italic> now provide support for this concept in a study of mice genetically predisposed to develop acute myeloid leukemia. Early administration of an epigenetic therapy that had previously been shown to have anticancer activity in advanced leukemia models was able to eliminate preleukemia cells and extend survival of the mice. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6477" page="586" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax5863">586</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 586-590
Avoiding immigration limbo
Jaivime Evaristo
Palabras clave: Multidisciplinary.
Pp. 594-594
Another HIV vaccine strategy fails in large-scale study
Jon Cohen
Palabras clave: Multidisciplinary.
Pp. No disponible
Study claiming new coronavirus can be transmitted by people without symptoms was flawed
Kai Kupferschmidt
Palabras clave: Multidisciplinary.
Pp. No disponible
U.S. prosecutor leading China probe explains effort that led to charges against Harvard chemist
Jeffrey Mervis
Palabras clave: Multidisciplinary.
Pp. No disponible
Colombia’s first ever science minister faces calls to resign over fungi-based cancer treatment
Rodrigo Pérez Ortega
Palabras clave: Multidisciplinary.
Pp. No disponible
Samples from famed 19th century voyage reveal ‘shocking’ effects of ocean acidification
Erin Malsbury
Palabras clave: Multidisciplinary.
Pp. No disponible
BRAIN Initiative’s first director sets sights on clinical tools
Kelly Servick
Palabras clave: Multidisciplinary.
Pp. No disponible
Florida state legislator fears overreaction in probe of foreign research ties
Jeffrey Mervis
Palabras clave: Multidisciplinary.
Pp. No disponible