Catálogo de publicaciones - revistas

<jats:title>Small burden from old sources</jats:title> <jats:p> Methane is a potent greenhouse gas with large natural sources, reservoirs, and sinks. Dyonisius <jats:italic>et al.</jats:italic> found that methane emissions from old, cold-region carbon reservoirs like permafrost and methane hydrates were minor during the last deglaciation (see the Perspective by Dean). They analyzed the carbon isotopic composition of atmospheric methane trapped in bubbles in Antarctic ice and found that methane emissions from those old carbon sources during the warming interval were small. They argue that this finding suggests that methane emissions in response to future warming likely will not be as large as some have suggested. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="907" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aax0504">907</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="846" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aba8518">846</jats:related-article> </jats:p>

<jats:title>These bees have “seen” that before</jats:title> <jats:p> Humans excel at mental imagery, and we can transfer those images across senses. For example, an object out of view, but for which we have a mental image, can still be recognized by touch. Such cross-modal recognition is highly adaptive and has been recently identified in other mammals, but whether it is widespread has been debated. Solvi <jats:italic>et al.</jats:italic> tested for this behavior in bumble bees, which are increasingly recognized as having some relatively advanced cognitive skills (see the Perspective by von der Emde and Burt de Perera). They found that the bees could identify objects by shape in the dark if they had seen, but not touched, them in the light, and vice versa, demonstrating a clear ability to transmit recognition across senses. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="910" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aay8064">910</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="850" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aba8519">850</jats:related-article> </jats:p>

<jats:title>Evolution of a kinase allosteric site</jats:title> <jats:p> Enzyme activity is often regulated by conformational changes coupled to binding of an effector at an allosteric site, a feature especially important for enzymes involved in signaling cascades. Hadzipasic <jats:italic>et al.</jats:italic> studied the origins of allosteric regulation of Aurora A, a kinase involved in progression of the eukaryotic cell cycle. Aurora A is allosterically regulated through the binding of an effector protein named TPX2, which also targets the kinase to spindle microtubules. By reconstructing ancestor kinase sequences, they found that TPX2 bound to an early Aurora A but had very weak activation that was gradually strengthened by evolution of an allosteric network within the kinase. An evolutionary advantage from localizing the active protein at the mitotic spindle may have driven the development of this regulatory mechanism. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="912" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aay9959">912</jats:related-article> </jats:p>

<jats:title>Enzymes lock in planar chirality</jats:title> <jats:p> Molecules with very large rings—macrocycles—are often conformationally constrained, and some exhibit planar chirality when substituents of the ring cannot rotate freely. Restricted rotation is generally valued in macrocycles because it can hold the molecule in functional conformations. Using a well-established lipase enzyme, Gagnon <jats:italic>et al.</jats:italic> developed a synthesis of planar chiral macrocycles with handles that can be easily functionalized. Computational docking suggests how using an enzyme as the catalyst for sequential acylation reactions can impart the observed stereochemistry. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="917" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aaz7381">917</jats:related-article> </jats:p>

<jats:p> The 2020 Gordon Research Conference schedule was published on pages 922 to 945 of this issue of the print version of <jats:italic>Science</jats:italic> . The current schedule can also be found online at <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.grc.org/">www.grc.org/</jats:ext-link> . </jats:p>