Catálogo de publicaciones - revistas

<jats:title>Dating the Drimolen hominins</jats:title> <jats:p> Fossil hominins from South Africa are enriching the story of early human evolution and dispersal. Herries <jats:italic>et al.</jats:italic> describe the geological context and dating of the hominin-bearing infilled cave, or palaeocave, at a site called Drimolen in South Africa (see the Perspective by Antón). They focus on the age and context of a recently discovered <jats:italic>Homo erectus sensu lato fossil and a Paranthropus robustus</jats:italic> fossil, which they dated to ∼2.04 million to 1.95 million years ago. This makes Drimolen one of the best-dated sites in South Africa and establishes these fossils as the oldest definitive specimens of their respective species ever discovered. The age confirms that species of <jats:italic>Australopithecus, Paranthropus</jats:italic> , and early <jats:italic>Homo</jats:italic> overlapped in the karst of South Africa ∼2 million years ago. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw7293">eaaw7293</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6486" page="34" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb4590">34</jats:related-article> </jats:p>

<jats:title>Root growth regulation by requirement</jats:title> <jats:p>Plant productivity depends on the elemental nutrients nitrogen and phosphorus, which are drawn from the soil. Oldroyd and Leyser review how root growth patterns adjust according to the physiological needs of the above-ground plant. Systemic signals, including small peptide signals, mediate communication between the shoot's needs and the root's supply.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba0196">eaba0196</jats:related-article> </jats:p>

<jats:title>DNA death grip</jats:title> <jats:p> Poly(ADP-ribose) polymerase–1 (PARP-1) binds to DNA breaks and recruits DNA repair components. Cancer-killing PARP-1 inhibitor (PARPi) compounds all block the same catalytic site but exhibit vastly different efficacy. Zandarashvili <jats:italic>et al.</jats:italic> investigated the molecular impact of PARPi binding to PARP-1 (see the Perspective by Slade and Eustermann). Different PARPi molecules perturb PARP-1 allostery in diverse manners: Some drive allostery to promote release of PARP-1 from DNA, and others drive allostery to promote retention. These insights help explain the different efficacies in the clinic and enable conversion of a pro-release, ineffective cancer-killing compound to a pro-retention, more effective PARPi. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax6367">eaax6367</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6486" page="30" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb1462">30</jats:related-article> </jats:p>

<jats:p> Last week, we ran what is likely to be one of the most widely read <jats:italic>Science</jats:italic> news stories ever—an interview with Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases (NIAID). Fauci was strikingly candid about his desire for extraordinary measures to combat coronavirus disease 2019 (COVID-19), and he was unusually direct about the challenges in getting the administration to see how important it is for the country to maintain social distancing. </jats:p>

<jats:p>A future driven by artificial intelligence (AI) is often depicted as one paved with improvements across every aspect of life—from health, to jobs, to how we connect. But cracks in this utopia are starting to appear, particularly as we glimpse how AI can also be used to surveil, discriminate, and cause other harms. What existing legal frameworks can protect us from the dark side of this brave new world of technology?</jats:p>