Catálogo de publicaciones - revistas

<jats:title>Elesclomol rescues Menkes disease mice</jats:title> <jats:p> Menkes disease results from loss-of-function mutations in the P-type copper-transporting adenosine triphosphatase ATP7A. Children diagnosed with Menkes present with connective tissue abnormalities and neurodegenerative changes that result in death caused by severe copper deficiency, typically before 3 years of age. In the brain, lack of copper impairs cytochrome c oxidase (complex IV) in the electron transport chain, which leads to progressive neurological injury in Menkes patients. No treatment exists for Menkes disease because of the difficulty in supplying the brain with copper using traditional hydrophilic copper complexes such as copper histidine. Guthrie <jats:italic>et al.</jats:italic> developed a treatment involving the drug elesclomol that successfully alleviated disease symptoms in a mouse model of Menkes disease (see the Perspective by Lutsenko). </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="620" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.aaz8899">620</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="584" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb6662">584</jats:related-article> </jats:p>

<jats:title>Ultracold molecular collision dynamics</jats:title> <jats:p> Ultracold collision dynamics are of great importance in understanding the quantum nature of chemical interactions, but achieving the ultracold regime for molecules is challenging. Traditional techniques based on alternative routes to assemble the ultracold atomic constituents are only able to produce a type of ultracold molecules that cannot probe state-selective dynamics. Using Stark deceleration and velocity map–imaging techniques, de Jongh <jats:italic>et al.</jats:italic> achieved the ultracold regime directly for a nitric oxide–helium system and measured the state-to-state cross sections for inelastic scattering with high precision (see the Perspective by Yang and Yang). The observed scattering resonances confirmed high sensitivity to the underlying interaction potential because only the most accurate electronic structure theory could reproduce their structure. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="626" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.aba3990">626</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="582" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb8020">582</jats:related-article> </jats:p>

<jats:title>Targeting the SARS-CoV-2 spike</jats:title> <jats:p> The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors. These spikes also elicit an antibody response, so understanding antibody recognition may aid in vaccine design. Yuan <jats:italic>et al.</jats:italic> determined the structure of CR3022, a neutralizing antibody obtained from a convalescent SARS-CoV–infected patient, in complex with the receptor-binding domain of the SARS-CoV-2 spike. The antibody binds to an epitope conserved between SARS-CoV-2 and SARS-CoV that is distinct from the receptor-binding site. CR3022 likely binds more tightly to SARS-CoV because its epitope contains a glycan not present in SARS-CoV-2. Structural modeling showed that the epitope is only revealed when at least two of the three spike proteins are in a conformation competent to bind the receptor. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="630" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb7269">630</jats:related-article> </jats:p>

<jats:title>Sensing surfaces like a mosquito</jats:title> <jats:p> Although sonar or lidar are used by autonomous vehicles to detect nearby objects, these approaches incur significant equipment and signal-processing costs. Nakata <jats:italic>et al.</jats:italic> show that mosquitos detect surfaces using the flow fields caused by the movement of their own wings (see the Perspective by Young and Garratt). Near surfaces, there are small changes in the pressure and velocity that mosquitos can detect using their sensitive antennae. The authors translated this process into a simple, low-cost approach for detecting surfaces near a flying quadcopter. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="634" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.aaz9634">634</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="586" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb0064">586</jats:related-article> </jats:p>

<jats:title>The most effective interventions</jats:title> <jats:p> By 23 January 2020, China had imposed a national emergency response to restrict travel and impose social distancing measures on its populace in an attempt to inhibit the transmission of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2). However, which measures were most effective is uncertain. Tian <jats:italic>et al.</jats:italic> performed a quantitative analysis of the impact of control measures between 31 December 2019 and 19 February 2020, which encompasses the Lunar New Year period when millions of people traveled across China for family visits. Travel restrictions in and out of Wuhan were too late to prevent the spread of the virus to 262 cities within 28 days. However, the epidemic peaked in Hubei province on 4 February 2020, indicating that measures such as closing citywide public transport and entertainment venues and banning public gatherings combined to avert hundreds of thousands of cases of infection. It is unlikely that this decline happened because the supply of susceptible people was exhausted, so relaxing control measures could lead to a resurgence. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6491" page="638" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abb6105">638</jats:related-article> </jats:p>