Catálogo de publicaciones - revistas

<jats:title>Changing views and a changing ocean</jats:title> <jats:p> As a component of many biomolecules, nitrogen is a crucial element for life, especially in nutrient-poor environs such as the open ocean. Atmospheric dinitrogen gas (N <jats:sub>2</jats:sub> ) is abundant but must be fixed by reduction to ammonia, a process limited to certain organisms and environments. Zehr and Capone review changes in our understanding of what marine microorganisms are fixing N <jats:sub>2</jats:sub> , where they live, and what environmental features influence their activity. N <jats:sub>2</jats:sub> fixation is more widely distributed than previously thought, and we still have much to learn about the physiology and regulation involved. We now have better estimates of global- and basin-scale inputs and outputs, but questions remain as to whether the oceanic N cycle is balanced. New tools are enabling better understanding of ocean N <jats:sub>2</jats:sub> fixation despite disruptive consequences from human activities, including ocean acidification and warming. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay9514">eaay9514</jats:related-article> </jats:p>

<jats:p>Hu and Ruckenstein state that our findings were overclaimed and not new, despite our presentation of evidence for the Nanocatalysts on Single Crystal Edges (NOSCE) mechanism. Their arguments do not take into account fundamental differences between our Ni-Mo/MgO catalyst and their NiO/MgO preparations.</jats:p>

<jats:p> Song <jats:italic>et al</jats:italic> . (Reports, 14 February 2020, p. 777) ignore the reported efficient Ni/MgO solid-solution catalysts and overstate the novelty and importance of the Mo-doped Ni/MgO catalysts for the dry reforming of methane. We show that the Ni/MgO solid-solution catalyst that we reported in 1995, which is efficient and stable for the dry reforming, is superior to the Mo-doped Ni/MgO catalyst. </jats:p>

<jats:title>TopoBuilding precision vaccines</jats:title> <jats:p> To induce strong and targeted neutralizing antibody (nAb) responses against vaccine targets, one strategy has been to use computationally designed immunogens. However, the structural complexity of many known neutralization epitopes has posed a major challenge for the design of accurate epitope mimetics. Sesterhenn <jats:italic>et al.</jats:italic> created a protein design algorithm called TopoBuilder to design scaffolds for irregular and discontinuous neutralization epitopes. As a proof of principle, the authors generated epitope-focused immunogens based on the prefusion conformation of the respiratory syncytial virus (RSV) fusion protein. When these immunogens were used to vaccinate mice and nonhuman primates in RSV infection models, they generated targeted nAb responses to RSV and boosted site-specific nAb responses in heterologous prime-boost vaccination schemes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay5051">eaay5051</jats:related-article> </jats:p>

<jats:p>Before the coronavirus disease 2019 (COVID-19) pandemic, nuance and candor from governments were in short supply. Now they are almost nonexistent. Protecting the world from severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) can't happen without international scientific collaboration. Progress on vaccines in China and the United States should make us optimistic that science will solve this problem, but the actions of the governments involved are not equally inspiring.</jats:p>