Catálogo de publicaciones - revistas

<jats:title>Cell-cell contacts specify cell fate</jats:title> <jats:p> Ascidians, or sea squirts, are marine invertebrate filter feeders with highly reproducible cellular events and invariant embryonic cell lineages. Guignard <jats:italic>et al.</jats:italic> studied the ascidian embryo to address the determinants of this cellular reproducibility. They introduce computational methods for the robust and automated segmentation, tracking, and analysis of whole-cell behaviors in high-throughput light-sheet microscopy datasets. This work shows that cell induction can be controlled by the contact area among cells. The range of cell signaling is proposed to set the scale at which animal embryonic reproducibility is observed. A high level of reproducibility of embryonic geometries may also counter-intuitively lift constraints on genome evolution, thereby contributing to the rapid molecular evolution observed in ascidians. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aar5663">eaar5663</jats:related-article> </jats:p>

<jats:title>Roles of organ-specific lymphatic vessels</jats:title> <jats:p> Lymphatic vessels are spread throughout the human body and have critical functions in mammalian physiology. Petrova <jats:italic>et al.</jats:italic> review emerging roles of the lymphatic vasculature in organ function and pathology and provide perspectives beyond the traditional view of lymphatic vessels in the maintenance of fluid homeostasis. The authors highlight new insights into lymphatic vessel function and lymphatic endothelial cell biology as it relates to intestinal lacteals, lymph nodes, central nervous system meninges, and cancer. Recent steps toward therapeutic opportunities that could alter lymphatic function or growth are also discussed. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax4063">eaax4063</jats:related-article> </jats:p>

<jats:title>Brain barrier and support in a dish</jats:title> <jats:p> Deep within the brain, the choroid plexus filters blood and secretes cerebrospinal fluid (CSF), a nutrient-rich liquid that bathes and supports the brain and protects it from entry of toxic compounds. Current understanding of this vital tissue in humans is limited. Pellegrini <jats:italic>et al.</jats:italic> developed choroid plexus organoids that quantitatively predict human brain permeability of small molecules and secrete an isolated CSF-like fluid (see the Perspective by Silva-Vargas and Doetsch). This CSF model reveals secretion of developmental factors and disease-related biomarkers by key cell types and provides a testing ground for drug entry into the brain. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaz5626">eaaz5626</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6500" page="143" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abd0269">143</jats:related-article> </jats:p>

<jats:title>Keeping the lid on infection spread</jats:title> <jats:p> From February to April 2020, many countries introduced variations on social distancing measures to slow the ravages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Publicly available data show that Germany has been particularly successful in minimizing death rates. Dehning <jats:italic>et al.</jats:italic> quantified three governmental interventions introduced to control the outbreak. The authors predicted that the third governmental intervention—a strict contact ban since 22 March—switched incidence from growth to decay. They emphasize that relaxation of controls must be done carefully, not only because there is a 2-week lag between a measure being enacted and the effect on case reports but also because the three measures used in Germany only just kept virus spread below the growth threshold. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb9789">eabb9789</jats:related-article> </jats:p>

<jats:p>I am a scientist. I am an American. And I am the product of special expert visas and chain migration—among the many types of legal immigration into the United States. On 22 June, President Trump issued a proclamation that temporarily restricts many types of legal immigration into the country, including that of scientists and students. This will make America neither greater nor safer—rather, it could make America less so.</jats:p>