Catálogo de publicaciones - revistas

<jats:title>Deconstructing a perilous loop</jats:title> <jats:p> Cancer cells that give rise to solid tumors reside in a specialized microenvironment containing growth factors that support tumor growth and progression. The mechanisms by which tumor cells within this so-called “niche” attract and sustain these growth factors are poorly understood. Studying a mouse model of squamous cell carcinoma, Taniguchi <jats:italic>et al.</jats:italic> identified a signaling loop initiated by certain tumor cells within the niche that become more invasive on exposure to transforming growth factor β (TGF-β). They show that the tumor cells release the cytokine interleukin-33, which induces the differentiation of nearby myeloid cells into macrophages. These macrophages in turn release TGF-β, which feeds back to the tumor cells, promoting their malignant progression. </jats:p> <jats:p> <jats:italic>Science</jats:italic> this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay1813">eaay1813</jats:related-article> </jats:p>

<jats:title>Conservation help from genomics</jats:title> <jats:p> Corals worldwide are under threat from rising sea temperatures and pollution. One response to heat stress is coral bleaching—the loss of photosynthetic endosymbionts that provide energy for the coral. Fuller <jats:italic>et al.</jats:italic> present a high-resolution genome of the coral <jats:italic>Acropora millepora</jats:italic> (see the Perspective by Bay and Guerrero). They were able to perform population genetic analyses with samples sequenced at lower coverage and conduct genome-wide association studies. These data were combined to generate a polygenic risk score for bleaching that can be used in coral conservation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba4674">eaba4674</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6501" page="249" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abc9342">249</jats:related-article> </jats:p>

<jats:title>An optical timekeeper</jats:title> <jats:p> Optical clocks, based on optical transitions of atoms, operate at much higher frequency than the microwave atomic clocks currently used as our timing standards. They have been shown to exhibit better stability and are poised to redefine the second. The development of stable, self-referenced optical frequency combs that span the microwave to optical wavelengths has been key to these efforts. Diddams <jats:italic>et al.</jats:italic> reviewed developments and refinements of these optical combs over the past 20 years and provide an overview of where they are finding application, from precision timing to high-resolution spectroscopy and imaging, ranging, and navigation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay3676">eaay3676</jats:related-article> </jats:p>