Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
Kui K. Chan
; Danielle Dorosky; Preeti Sharma; Shawn A. Abbasi; John M. Dye; David M. Kranz; Andrew S. Herbert; Erik Procko
<jats:title>A decoy receptor for SARS-CoV-2</jats:title> <jats:p> For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells, the spike protein on the surface of the virus must bind to the host receptor protein, angiotensin-converting enzyme 2 (ACE2). A soluble version of the receptor is being explored as a therapeutic. Chan <jats:italic>et al.</jats:italic> used deep mutagenesis to identify ACE2 mutants that bind more tightly to the spike protein and combined mutations to further increase binding affinity (see the Perspective by DeKosky). A promising variant was engineered to be a stable dimer that has a binding affinity for the spike protein; it is comparable with neutralizing antibodies and neutralized both SARS-CoV-2 and SARS-CoV-1 in a cell-based assay. In addition, the similarity to the natural receptor may limit the possibility for viral escape. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6508" page="1261" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abc0870">1261</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6508" page="1167" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abe0010">1167</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1261-1265
New Products
<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1266-1266
Mentoring with trust
René S. Shahmohamadloo
Palabras clave: Multidisciplinary.
Pp. 1270-1270
Ocean warming has seafloor species headed in the wrong direction
Erik Stokstad
Palabras clave: Multidisciplinary.
Pp. No disponible
One of quantum physics’ greatest paradoxes may have lost its leading explanation
George Musser
Palabras clave: Multidisciplinary.
Pp. No disponible
How German military scientists likely identified the nerve agent used to attack Alexei Navalny
Richard Stone
Palabras clave: Multidisciplinary.
Pp. No disponible
To survive frigid nights, hummingbirds cool themselves to record-low temperatures
Lucy Hicks
Palabras clave: Multidisciplinary.
Pp. No disponible
Why COVID-19 is more deadly in people with obesity—even if they're young
Meredith Wadman
Palabras clave: Multidisciplinary.
Pp. No disponible
Dozens of scientific journals have vanished from the internet, and no one preserved them
Jeffrey Brainard
Palabras clave: Multidisciplinary.
Pp. No disponible
How to network during challenging times
Alaina Levine
Palabras clave: Multidisciplinary.
Pp. No disponible