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<jats:p>For more than 200 years, U.S. presidents have strived to deliver words of inspiration and humility that will stand the test of time. Even in a contentious debate in which the Oval Office is at stake, we expect a standing president to inspire and unite the country. Not surprisingly, President Donald Trump used the occasion of the first presidential debate of 2020 to deny reality, insult his opponent, and praise himself—all with his customary lean vocabulary.</jats:p>

<jats:p> Braun <jats:italic>et al</jats:italic> . contend that we did not account for survival, but we did. Differential survival does not alter our conclusions, which were also robust to removing anomalous families. They ignore the study system’s natural history justifying our fitness measures, while failing to account for our behavioral data. We stand by our conclusion that females adaptively choose among heterospecific males. </jats:p>

<jats:p>Chen and Pfennig (Reports, 20 March 2020, p. 1377) analyze the fitness consequences of hybridization in toads but do not account for differences in survival among progeny. Apparent fitness effects depend on families with anomalously low survival, yet survival is crucial to evolutionary fitness. This and other analytical shortcomings demonstrate that a conclusion of adaptive mate choice is not yet justified.</jats:p>

<jats:title>Evolution of bioengineered blood vessels</jats:title> <jats:p>Biotechnology approaches to repair and replace arteries have been under development for more than a century. Early synthetic approaches used rubber-based replacements, which then evolved into the use of polymer fabrics and, more recently, into biological approaches that permit the growth of blood vessels in the laboratory. Niklason and Lawson review the scientific and technological advances that allow the regeneration of a patient's own blood vessels. The authors discuss how blood vessel cells, when combined with suitable substrates for tissue growth under conditions that mimic human physiology, can produce functional bioengineered arteries. These biological approaches pave the way to advancing how vascular disease is managed and treated in the future.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw8682">eaaw8682</jats:related-article> </jats:p>