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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity
Emma U. Hammarlund
; Emily Flashman; Sofie Mohlin; Francesco Licausi
<jats:title>Origins and evolution of hypoxia response</jats:title> <jats:p> In our current oxygen-rich atmosphere, the ability of eukaryotic cells to sense variation in oxygen concentrations is essential for adapting to low-oxygen conditions. However, Earth's atmosphere has not always contained such high oxygen concentrations. Hammarlund <jats:italic>et al.</jats:italic> discuss oxygen-sensing systems across both plants and animals and argue that the systems are functionally convergent and that their emergence in an initially hypoxic environment shaped how they operate today. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba3512">eaba3512</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Deep abiotic weathering of pyrite
Xin Gu; Peter J. Heaney; Fabio D. A. Aarão Reis; Susan L. Brantley
<jats:title>Getting rid of fool's gold</jats:title> <jats:p> Pyrite, also called fool's gold, is an iron sulfide mineral that is very commonly found in rock but is almost nonexistent in sediments today. Pyrite oxidizes quickly and is a major source of sulfur to the ocean, but it is also a proxy for the oxygen content historically in Earth's atmosphere. Gu <jats:italic>et al.</jats:italic> conducted a set of detailed observations of the pyrite oxidation process in a shale unit. The authors found that erosion tied to fracturing is just as important as the oxygen content for the dissolution process. They developed a model that helps determine the conditions in Earth's past for which pyrite might have been stable and the role of microorganisms in the oxidation process. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb8092">eabb8092</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Erratum for the Report “Meta-analysis reveals declines in terrestrial but increases in freshwater insect abundances” by R. Van Klink, D. E. Bowler, K. B. Gongalsky, A. B. Swengel, A. Gentile, J. M. Chase
Palabras clave: Multidisciplinary.
Pp. No disponible
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Qian Zhang; Paul Bastard; Zhiyong Liu; Jérémie Le Pen; Marcela Moncada-Velez; Jie Chen; Masato Ogishi; Ira K. D. Sabli; Stephanie Hodeib; Cecilia Korol; Jérémie Rosain; Kaya Bilguvar; Junqiang Ye; Alexandre Bolze; Benedetta Bigio; Rui Yang; Andrés Augusto Arias; Qinhua Zhou; Yu Zhang; Fanny Onodi; Sarantis Korniotis; Léa Karpf; Quentin Philippot; Marwa Chbihi; Lucie Bonnet-Madin; Karim Dorgham; Nikaïa Smith; William M. Schneider; Brandon S. Razooky; Hans-Heinrich Hoffmann; Eleftherios Michailidis; Leen Moens; Ji Eun Han; Lazaro Lorenzo; Lucy Bizien; Philip Meade; Anna-Lena Neehus; Aileen Camille Ugurbil; Aurélien Corneau; Gaspard Kerner; Peng Zhang; Franck Rapaport; Yoann Seeleuthner; Jeremy Manry; Cecile Masson; Yohann Schmitt; Agatha Schlüter; Tom Le Voyer; Taushif Khan; Juan Li; Jacques Fellay; Lucie Roussel; Mohammad Shahrooei; Mohammed F. Alosaimi; Davood Mansouri; Haya Al-Saud; Fahd Al-Mulla; Feras Almourfi; Saleh Zaid Al-Muhsen; Fahad Alsohime; Saeed Al Turki; Rana Hasanato; Diederik van de Beek; Andrea Biondi; Laura Rachele Bettini; Mariella D’Angio’; Paolo Bonfanti; Luisa Imberti; Alessandra Sottini; Simone Paghera; Eugenia Quiros-Roldan; Camillo Rossi; Andrew J. Oler; Miranda F. Tompkins; Camille Alba; Isabelle Vandernoot; Jean-Christophe Goffard; Guillaume Smits; Isabelle Migeotte; Filomeen Haerynck; Pere Soler-Palacin; Andrea Martin-Nalda; Roger Colobran; Pierre-Emmanuel Morange; Sevgi Keles; Fatma Çölkesen; Tayfun Ozcelik; Kadriye Kart Yasar; Sevtap Senoglu; Şemsi Nur Karabela; Carlos Rodríguez-Gallego; Giuseppe Novelli; Sami Hraiech; Yacine Tandjaoui-Lambiotte; Xavier Duval; Cédric Laouénan; Andrew L. Snow; Clifton L. Dalgard; Joshua D. Milner; Donald C. Vinh; Trine H. Mogensen; Nico Marr; András N. Spaan; Bertrand Boisson; Stéphanie Boisson-Dupuis; Jacinta Bustamante; Anne Puel; Michael J. Ciancanelli; Isabelle Meyts; Tom Maniatis; Vassili Soumelis; Ali Amara; Michel Nussenzweig; Adolfo García-Sastre; Florian Krammer; Aurora Pujol; Darragh Duffy; Richard P. Lifton; Shen-Ying Zhang; Guy Gorochov; Vivien Béziat; Emmanuelle Jouanguy; Vanessa Sancho-Shimizu; Charles M. Rice; Laurent Abel; Luigi D. Notarangelo; Aurélie Cobat; Helen C. Su; Jean-Laurent Casanova; Giuseppe Foti; Giacomo Bellani; Giuseppe Citerio; Ernesto Contro; Alberto Pesci; Maria Grazia Valsecchi; Marina Cazzaniga; Jorge Abad; Sergio Aguilera-Albesa; Ozge Metin Akcan; Ilad Alavi Darazam; Juan C. Aldave; Miquel Alfonso Ramos; Seyed Alireza Nadji; Gulsum Alkan; Jerome Allardet-Servent; Luis M. Allende; Laia Alsina; Marie-Alexandra Alyanakian; Blanca Amador-Borrero; Zahir Amoura; Arnau Antolí; Sevket Arslan; Sophie Assant; Terese Auguet; Axelle Azot; Fanny Bajolle; Aurélie Baldolli; Maite Ballester; Hagit Baris Feldman; Benoit Barrou; Alexandra Beurton; Agurtzane Bilbao; Geraldine Blanchard-Rohner; Ignacio Blanco; Adeline Blandinières; Daniel Blazquez-Gamero; Marketa Bloomfield; Mireia Bolivar-Prados; Raphael Borie; Cédric Bosteels; Ahmed A. Bousfiha; Claire Bouvattier; Oksana Boyarchuk; Maria Rita P. Bueno; Jacinta Bustamante; Juan José Cáceres Agra; Semra Calimli; Ruggero Capra; Maria Carrabba; Carlos Casasnovas; Marion Caseris; Martin Castelle; Francesco Castelli; Martín Castillo de Vera; Mateus V. Castro; Emilie Catherinot; Martin Chalumeau; Bruno Charbit; Matthew P. Cheng; Père Clavé; Bonaventura Clotet; Anna Codina; Fatih Colkesen; Fatma Çölkesen; Roger Colobran; Cloé Comarmond; David Dalmau; David Ross Darley; Nicolas Dauby; Stéphane Dauger; Loic de Pontual; Amin Dehban; Geoffroy Delplancq; Alexandre Demoule; Jean-Luc Diehl; Stephanie Dobbelaere; Sophie Durand; Waleed Eldars; Mohamed Elgamal; Marwa H. Elnagdy; Melike Emiroglu; Emine Hafize Erdeniz; Selma Erol Aytekin; Romain Euvrard; Recep Evcen; Giovanna Fabio; Laurence Faivre; Antonin Falck; Muriel Fartoukh; Morgane Faure; Miguel Fernandez Arquero; Carlos Flores; Bruno Francois; Victoria Fumadó; Francesca Fusco; Blanca Garcia Solis; Pascale Gaussem; Juana Gil-Herrera; Laurent Gilardin; Monica Girona Alarcon; Mònica Girona-Alarcón; Jean-Christophe Goffard; Funda Gok; Rafaela González-Montelongo; Antoine Guerder; Yahya Gul; Sukru Nail Guner; Marta Gut; Jérôme Hadjadj; Filomeen Haerynck; Rabih Halwani; Lennart Hammarström; Nevin Hatipoglu; Elisa Hernandez-Brito; Cathérine Heijmans; María Soledad Holanda-Peña; Juan Pablo Horcajada; Levi Hoste; Eric Hoste; Sami Hraiech; Linda Humbert; Alejandro D. Iglesias; Antonio Íñigo-Campos; Matthieu Jamme; María Jesús Arranz; Iolanda Jordan; Philippe Jorens; Fikret Kanat; Hasan Kapakli; Iskender Kara; Adem Karbuz; Kadriye Kart Yasar; Sevgi Keles; Yasemin Kendir Demirkol; Adam Klocperk; Zbigniew J. Król; Paul Kuentz; Yat Wah M. Kwan; Jean-Christophe Lagier; Bart N. Lambrecht; Yu-Lung Lau; Fleur Le Bourgeois; Yee-Sin Leo; Rafael Leon Lopez; Daniel Leung; Michael Levin; Michael Levy; Romain Lévy; Zhi Li; Agnes Linglart; Bart Loeys; José M. Lorenzo-Salazar; Céline Louapre; Catherine Lubetzki; Charles-Edouard Luyt; David C. Lye; Davood Mansouri; Majid Marjani; Jesus Marquez Pereira; Andrea Martin; David Martínez Pueyo; Javier Martinez-Picado; Iciar Marzana; Alexis Mathian; Larissa R. B. Matos; Gail V. Matthews; Julien Mayaux; Jean-Louis Mège; Isabelle Melki; Jean-François Meritet; Ozge Metin; Isabelle Meyts; Mehdi Mezidi; Isabelle Migeotte; Maude Millereux; Tristan Mirault; Clotilde Mircher; Mehdi Mirsaeidi; Abián Montesdeoca Melián; Antonio Morales Martinez; Pierre Morange; Clémence Mordacq; Guillaume Morelle; Stéphane Mouly; Adrián Muñoz-Barrera; Leslie Naesens; Cyril Nafati; João Farela Neves; Lisa F. P. Ng; Yeray Novoa Medina; Esmeralda Nuñez Cuadros; J. Gonzalo Ocejo-Vinyals; Zerrin Orbak; Mehdi Oualha; Tayfun Özçelik; Qiang Pan-Hammarström; Christophe Parizot; Tiffany Pascreau; Estela Paz-Artal; Sandra Pellegrini; Rebeca Pérez de Diego; Aurélien Philippe; Quentin Philippot; Laura Planas-Serra; Dominique Ploin; Julien Poissy; Géraldine Poncelet; Marie Pouletty; Paul Quentric; Didier Raoult; Anne-Sophie Rebillat; Ismail Reisli; Pilar Ricart; Jean-Christophe Richard; Nadia Rivet; Jacques G. Rivière; Gemma Rocamora Blanch; Carlos Rodrigo; Carlos Rodriguez-Gallego; Agustí Rodríguez-Palmero; Carolina Soledad Romero; Anya Rothenbuhler; Flore Rozenberg; Maria Yolanda Ruiz del Prado; Joan Sabater Riera; Oliver Sanchez; Silvia Sánchez-Ramón; Agatha Schluter; Matthieu Schmidt; Cyril E. Schweitzer; Francesco Scolari; Anna Sediva; Luis M. Seijo; Damien Sene; Sevtap Senoglu; Mikko R. J. Seppänen; Alex Serra Ilovich; Mohammad Shahrooei; Hans Slabbynck; David M. Smadja; Ali Sobh; Xavier Solanich Moreno; Jordi Solé-Violán; Catherine Soler; Pere Soler-Palacín; Yuri Stepanovskiy; Annabelle Stoclin; Fabio Taccone; Yacine Tandjaoui-Lambiotte; Jean-Luc Taupin; Simon J. Tavernier; Benjamin Terrier; Caroline Thumerelle; Gabriele Tomasoni; Julie Toubiana; Josep Trenado Alvarez; Sophie Trouillet-Assant; Jesús Troya; Alessandra Tucci; Matilde Valeria Ursini; Yurdagul Uzunhan; Pierre Vabres; Juan Valencia-Ramos; Eva Van Braeckel; Stijn Van de Velde; Ana Maria Van Den Rym; Jens Van Praet; Isabelle Vandernoot; Hulya Vatansev; Valentina Vélez-Santamaria; Sébastien Viel; Cédric Vilain; Marie E. Vilaire; Audrey Vincent; Guillaume Voiriot; Fanny Vuotto; Alper Yosunkaya; Barnaby E. Young; Fatih Yucel; Faiez Zannad; Mayana Zatz; Alexandre Belot; Christine Bole-Feysot; Stanislas Lyonnet; Cécile Masson; Patrick Nitschke; Aurore Pouliet; Yoann Schmitt; Frederic Tores; Mohammed Zarhrate; Laurent Abel; Claire Andrejak; François Angoulvant; Delphine Bachelet; Romain Basmaci; Sylvie Behillil; Marine Beluze; Dehbia Benkerrou; Krishna Bhavsar; François Bompart; Lila Bouadma; Maude Bouscambert; Mireille Caralp; Minerva Cervantes-Gonzalez; Anissa Chair; Alexandra Coelho; Camille Couffignal; Sandrine Couffin-Cadiergues; Eric D’Ortenzio; Charlene Da Silveira; Marie-Pierre Debray; Dominique Deplanque; Diane Descamps; Mathilde Desvallées; Alpha Diallo; Alphonsine Diouf; Céline Dorival; François Dubos; Xavier Duval; Philippine Eloy; Vincent VE Enouf; Hélène Esperou; Marina Esposito-Farese; Manuel Etienne; Nadia Ettalhaoui; Nathalie Gault; Alexandre Gaymard; Jade Ghosn; Tristan Gigante; Isabelle Gorenne; Jérémie Guedj; Alexandre Hoctin; Isabelle Hoffmann; Salma Jaafoura; Ouifiya Kafif; Florentia Kaguelidou; Sabina Kali; Antoine Khalil; Coralie Khan; Cédric Laouénan; Samira Laribi; Minh Le; Quentin Le Hingrat; Soizic Le Mestre; Hervé Le Nagard; François-Xavier Lescure; Yves Lévy; Claire Levy-Marchal; Bruno Lina; Guillaume Lingas; Jean Christophe Lucet; Denis Malvy; Marina Mambert; France Mentré; Noémie Mercier; Amina Meziane; Hugo Mouquet; Jimmy Mullaert; Nadège Neant; Marion Noret; Justine Pages; Aurélie Papadopoulos; Christelle Paul; Nathan Peiffer-Smadja; Ventzislava Petrov-Sanchez; Gilles Peytavin; Olivier Picone; Oriane Puéchal; Manuel Rosa-Calatrava; Bénédicte Rossignol; Patrick Rossignol; Carine Roy; Marion Schneider; Caroline Semaille; Nassima Si Mohammed; Lysa Tagherset; Coralie Tardivon; Marie-Capucine Tellier; François Téoulé; Olivier Terrier; Jean-François Timsit; Théo Trioux; Christelle Tual; Sarah Tubiana; Sylvie van der Werf; Noémie Vanel; Aurélie Veislinger; Benoit Visseaux; Aurélie Wiedemann; Yazdan Yazdanpanah; Loubna Alavoine; Karine K. A. Amat; Sylvie Behillil; Julia Bielicki; Patricia Bruijning; Charles Burdet; Eric Caumes; Charlotte Charpentier; Bruno Coignard; Yolande Costa; Sandrine Couffin-Cadiergues; Florence Damond; Aline Dechanet; Christelle Delmas; Diane Descamps; Xavier Duval; Jean-Luc Ecobichon; Vincent Enouf; Hélène Espérou; Wahiba Frezouls; Nadhira Houhou; Emila Ilic-Habensus; Ouifiya Kafif; John Kikoine; Quentin Le Hingrat; David Lebeaux; Anne Leclercq; Jonathan Lehacaut; Sophie Letrou; Bruno Lina; Jean-Christophe Lucet; Denis Malvy; Pauline Manchon; Milica Mandic; Mohamed Meghadecha; Justina Motiejunaite; Mariama Nouroudine; Valentine Piquard; Andreea Postolache; Caroline Quintin; Jade Rexach; Layidé Roufai; Zaven Terzian; Michael Thy; Sarah Tubiana; Sylvie van der Werf; Valérie Vignali; Benoit Visseaux; Yazdan Yazdanpanah; Michiel van Agtmael; Anna Geke Algera; Frank van Baarle; Diane Bax; Martijn Beudel; Harm Jan Bogaard; Marije Bomers; Lieuwe Bos; Michela Botta; Justin de Brabander; Godelieve de Bree; Matthijs C. Brouwer; Sanne de Bruin; Marianna Bugiani; Esther Bulle; O. Chouchane; Alex Cloherty; Paul Elbers; Lucas Fleuren; Suzanne Geerlings; Bart Geerts; Theo Geijtenbeek; Armand Girbes; Bram Goorhuis; Martin P. Grobusch; Florianne Hafkamp; Laura Hagens; Jorg Hamann; Vanessa Harris; Robert Hemke; Sabine M. Hermans; Leo Heunks; Markus W. Hollmann; Janneke Horn; Joppe W. Hovius; Menno D. de Jong; Rutger Koning; Niels van Mourik; Jeaninne Nellen; Frederique Paulus; Edgar Peters; Tom van der Poll; Benedikt Preckel; Jan M. Prins; Jorinde Raasveld; Tom Reijnders; Michiel Schinkel; Marcus J. Schultz; Alex Schuurman; Kim Sigaloff; Marry Smit; Cornelis S. Stijnis; Willemke Stilma; Charlotte Teunissen; Patrick Thoral; Anissa Tsonas; Marc van der Valk; Denise Veelo; Alexander P.J. Vlaar; Heder de Vries; Michèle van Vugt; W. Joost Wiersinga; Dorien Wouters; A. H. (Koos) Zwinderman; Diederik van de Beek; Laurent Abel; Alessandro Aiuti; Saleh Al Muhsen; Fahd Al-Mulla; Mark S. Anderson; Andrés Augusto Arias; Hagit Baris Feldman; Dusan Bogunovic; Alexandre Bolze; Anastasiia Bondarenko; Ahmed A. Bousfiha; Petter Brodin; Yenan Bryceson; Carlos D. Bustamante; Manish Butte; Giorgio Casari; Samya Chakravorty; John Christodoulou; Elizabeth Cirulli; Antonio Condino-Neto; Megan A. Cooper; Clifton L. Dalgard; Alessia David; Joseph L. DeRisi; Murkesh Desai; Beth A. Drolet; Sara Espinosa; Jacques Fellay; Carlos Flores; Jose Luis Franco; Peter K. Gregersen; Filomeen Haerynck; David Hagin; Rabih Halwani; Jim Heath; Sarah E. Henrickson; Elena Hsieh; Kohsuke Imai; Yuval Itan; Timokratis Karamitros; Kai Kisand; Cheng-Lung Ku; Yu-Lung Lau; Yun Ling; Carrie L. Lucas; Tom Maniatis; Davoud Mansouri; Laszlo Marodi; Isabelle Meyts; Joshua Milner; Kristina Mironska; Trine Mogensen; Tomohiro Morio; Lisa F. P. Ng; Luigi D. Notarangelo; Antonio Novelli; Giuseppe Novelli; Cliona O’Farrelly; Satoshi Okada; Tayfun Ozcelik; Rebeca Perez de Diego; Anna M. Planas; Carolina Prando; Aurora Pujol; Lluis Quintana-Murci; Laurent Renia; Alessandra Renieri; Carlos Rodríguez-Gallego; Vanessa Sancho-Shimizu; Vijay Sankaran; Kelly Schiabor Barrett; Mohammed Shahrooei; Andrew Snow; Pere Soler-Palacín; András N. Spaan; Stuart Tangye; Stuart Turvey; Furkan Uddin; Mohammed J. Uddin; Diederik van de Beek; Sara E. Vazquez; Donald C. Vinh; Horst von Bernuth; Nicole Washington; Pawel Zawadzki; Helen C. Su; Jean-Laurent Casanova; Huie Jing; Wesley Tung; Christopher R. Luthers; Bradly M. Bauman; Samantha Shafer; Lixin Zheng; Zinan Zhang; Satoshi Kubo; Samuel D. Chauvin; Kazuyuki Meguro; Elana Shaw; Michael Lenardo; Justin Lack; Eric Karlins; Daniel M. Hupalo; John Rosenberger; Gauthaman Sukumar; Matthew D. Wilkerson; Xijun Zhang; ; ; ; ; ; ; ;
<jats:title>The genetics underlying severe COVID-19</jats:title> <jats:p> The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang <jats:italic>et al.</jats:italic> used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and III IFN immunity. They found enrichment of these genes in patients and conclude that genetics may determine the clinical course of the infection. Bastard <jats:italic>et al.</jats:italic> identified individuals with high titers of neutralizing autoantibodies against type I IFN-α2 and IFN-ω in about 10% of patients with severe COVID-19 pneumonia. These autoantibodies were not found either in infected people who were asymptomatic or had milder phenotype or in healthy individuals. Together, these studies identify a means by which individuals at highest risk of life-threatening COVID-19 can be identified. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd4570">eabd4570</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd4585">eabd4585</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6515" page="404" related-article-type="in-this-issue" vol="370" xlink:href="10.1126/science.abe7591">404</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Design of higher valency in covalent organic frameworks
Cornelius Gropp; Tianqiong Ma; Nikita Hanikel; Omar M. Yaghi
<jats:title>Higher-valency ligands for COFs</jats:title> <jats:p> Metal-organic frameworks (MOFs) have exhibited more extensive connectivity (valency) and topological diversity than covalent organic frameworks (COFs), mainly because MOF linkers can connect from 3 to 24 discrete units or even infinity for one-dimensional rods. For COFs, linkers generally have a valency of 3 or 4 that reflect the valency of organic carbon. Gropp <jats:italic>et al.</jats:italic> created cubane-like linkers from 1,4-boronophenylphosphonic acid that could condense to make COFs with a valency of 8 or, by adding acid, could form large, single crystals with an infinite-rod topology. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd6406">eabd6406</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Paul Bastard; Lindsey B. Rosen; Qian Zhang; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Yu Zhang; Karim Dorgham; Quentin Philippot; Jérémie Rosain; Vivien Béziat; Jérémy Manry; Elana Shaw; Liis Haljasmägi; Pärt Peterson; Lazaro Lorenzo; Lucy Bizien; Sophie Trouillet-Assant; Kerry Dobbs; Adriana Almeida de Jesus; Alexandre Belot; Anne Kallaste; Emilie Catherinot; Yacine Tandjaoui-Lambiotte; Jeremie Le Pen; Gaspard Kerner; Benedetta Bigio; Yoann Seeleuthner; Rui Yang; Alexandre Bolze; András N. Spaan; Ottavia M. Delmonte; Michael S. Abers; Alessandro Aiuti; Giorgio Casari; Vito Lampasona; Lorenzo Piemonti; Fabio Ciceri; Kaya Bilguvar; Richard P. Lifton; Marc Vasse; David M. Smadja; Mélanie Migaud; Jérome Hadjadj; Benjamin Terrier; Darragh Duffy; Lluis Quintana-Murci; Diederik van de Beek; Lucie Roussel; Donald C. Vinh; Stuart G. Tangye; Filomeen Haerynck; David Dalmau; Javier Martinez-Picado; Petter Brodin; Michel C. Nussenzweig; Stéphanie Boisson-Dupuis; Carlos Rodríguez-Gallego; Guillaume Vogt; Trine H. Mogensen; Andrew J. Oler; Jingwen Gu; Peter D. Burbelo; Jeffrey I. Cohen; Andrea Biondi; Laura Rachele Bettini; Mariella D'Angio; Paolo Bonfanti; Patrick Rossignol; Julien Mayaux; Frédéric Rieux-Laucat; Eystein S. Husebye; Francesca Fusco; Matilde Valeria Ursini; Luisa Imberti; Alessandra Sottini; Simone Paghera; Eugenia Quiros-Roldan; Camillo Rossi; Riccardo Castagnoli; Daniela Montagna; Amelia Licari; Gian Luigi Marseglia; Xavier Duval; Jade Ghosn; John S. Tsang; Raphaela Goldbach-Mansky; Kai Kisand; Michail S. Lionakis; Anne Puel; Shen-Ying Zhang; Steven M. Holland; Guy Gorochov; Emmanuelle Jouanguy; Charles M. Rice; Aurélie Cobat; Luigi D. Notarangelo; Laurent Abel; Helen C. Su; Jean-Laurent Casanova; Andrés Augusto Arias; Bertrand Boisson; Soraya Boucherit; Jacinta Bustamante; Marwa Chbihi; Jie Chen; Maya Chrabieh; Tatiana Kochetkov; Tom Le Voyer; Dana Liu; Yelena Nemirovskaya; Masato Ogishi; Dominick Papandrea; Cécile Patissier; Franck Rapaport; Manon Roynard; Natasha Vladikine; Mark Woollett; Peng Zhang; Anuj Kashyap; Li Ding; Marita Bosticardo; Qinlu Wang; Sebastian Ochoa; Hui Liu; Samuel D. Chauvin; Michael Stack; Galina Koroleva; Neha Bansal; Clifton L. Dalgard; Andrew L. Snow; Jorge Abad; Sergio Aguilera-Albesa; Ozge Metin Akcan; Ilad Alavi Darazam; Juan C. Aldave; Miquel Alfonso Ramos; Seyed Alireza Nadji; Gulsum Alkan; Jerome Allardet-Servent; Luis M. Allende; Laia Alsina; Marie-Alexandra Alyanakian; Blanca Amador-Borrero; Zahir Amoura; Arnau Antolí; Sevket Arslan; Sophie Assant; Terese Auguet; Axelle Azot; Fanny Bajolle; Aurélie Baldolli; Maite Ballester; Hagit Baris Feldman; Benoit Barrou; Alexandra Beurton; Agurtzane Bilbao; Geraldine Blanchard-Rohner; Ignacio Blanco; Adeline Blandinières; Daniel Blazquez-Gamero; Marketa Bloomfield; Mireia Bolivar-Prados; Raphael Borie; Ahmed A. Bousfiha; Claire Bouvattier; Oksana Boyarchuk; Maria Rita P. Bueno; Jacinta Bustamante; Juan José Cáceres Agra; Semra Calimli; Ruggero Capra; Maria Carrabba; Carlos Casasnovas; Marion Caseris; Martin Castelle; Francesco Castelli; Martín Castillo de Vera; Mateus V. Castro; Emilie Catherinot; Martin Chalumeau; Bruno Charbit; Matthew P. Cheng; Père Clavé; Bonaventura Clotet; Anna Codina; Fatih Colkesen; Fatma Colkesen; Roger Colobran; Cloé Comarmond; Angelo G. Corsico; David Dalmau; David Ross Darley; Nicolas Dauby; Stéphane Dauger; Loic de Pontual; Amin Dehban; Geoffroy Delplancq; Alexandre Demoule; Antonio Di Sabatino; Jean-Luc Diehl; Stephanie Dobbelaere; Sophie Durand; Waleed Eldars; Mohamed Elgamal; Marwa H. Elnagdy; Melike Emiroglu; Emine Hafize Erdeniz; Selma Erol Aytekin; Romain Euvrard; Recep Evcen; Giovanna Fabio; Laurence Faivre; Antonin Falck; Muriel Fartoukh; Morgane Faure; Miguel Fernandez Arquero; Carlos Flores; Bruno Francois; Victoria Fumadó; Francesca Fusco; Blanca Garcia Solis; Pascale Gaussem; Juana Gil-Herrera; Laurent Gilardin; Monica Girona Alarcon; Mónica Girona-Alarcón; Jean-Christophe Goffard; Funda Gok; Rafaela González-Montelongo; Antoine Guerder; Yahya Gul; Sukru Nail Guner; Marta Gut; Jérôme Hadjadj; Filomeen Haerynck; Rabih Halwani; Lennart Hammarström; Nevin Hatipoglu; Elisa Hernandez-Brito; María Soledad Holanda-Peña; Juan Pablo Horcajada; Sami Hraiech; Linda Humbert; Alejandro D. Iglesias; Antonio Íñigo-Campos; Matthieu Jamme; María Jesús Arranz; Iolanda Jordan; Fikret Kanat; Hasan Kapakli; Iskender Kara; Adem Karbuz; Kadriye Kart Yasar; Sevgi Keles; Yasemin Kendir Demirkol; Adam Klocperk; Zbigniew J. Król; Paul Kuentz; Yat Wah M. Kwan; Jean-Christophe Lagier; Yu-Lung Lau; Fleur Le Bourgeois; Yee-Sin Leo; Rafael Leon Lopez; Daniel Leung; Michael Levin; Michael Levy; Romain Lévy; Zhi Li; Agnes Linglart; José M. Lorenzo-Salazar; Céline Louapre; Catherine Lubetzki; Charles-Edouard Luyt; David C. Lye; Davood Mansouri; Majid Marjani; Jesus Marquez Pereira; Andrea Martin; David Martínez Pueyo; Javier Martinez-Picado; Iciar Marzana; Alexis Mathian; Larissa R. B. Matos; Gail V. Matthews; Julien Mayaux; Jean-Louis Mège; Isabelle Melki; Jean-François Meritet; Ozge Metin; Isabelle Meyts; Mehdi Mezidi; Isabelle Migeotte; Maude Millereux; Tristan Mirault; Clotilde Mircher; Mehdi Mirsaeidi; Abián Montesdeoca Melián; Antonio Morales Martinez; Pierre Morange; Clémence Mordacq; Guillaume Morelle; Stéphane Mouly; Adrián Muñoz-Barrera; Cyril Nafati; João Farela Neves; Lisa F. P. Ng; Yeray Novoa Medina; Esmeralda Nuñez Cuadros; J. Gonzalo Ocejo-Vinyals; Zerrin Orbak; Mehdi Oualha; Tayfun Özçelik; Qiang Pan Hammarström; Christophe Parizot; Tiffany Pascreau; Estela Paz-Artal; Rebeca Pérez de Diego; Aurélien Philippe; Quentin Philippot; Laura Planas-Serra; Dominique Ploin; Julien Poissy; Géraldine Poncelet; Marie Pouletty; Paul Quentric; Didier Raoult; Anne-Sophie Rebillat; Ismail Reisli; Pilar Ricart; Jean-Christophe Richard; Nadia Rivet; Jacques G. 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Planas; Carolina Prando; Aurora Pujol; Lluis Quintana-Murci; Laurent Renia; Alessandra Renieri; Carlos Rodríguez-Gallego; Vanessa Sancho-Shimizu; Vijay Sankaran; Kelly Schiabor Barrett; Mohammed Shahrooei; Andrew Snow; Pere Soler-Palacín; András N. Spaan; Stuart Tangye; Stuart Turvey; Furkan Uddin; Mohammed J. Uddin; Diederik van de Beek; Sara E. Vazquez; Donald C. Vinh; Horst von Bernuth; Nicole Washington; Pawel Zawadzki; Helen C. Su; Jean-Laurent Casanova; ; ; ; ; ; ; ; ; ;
<jats:title>The genetics underlying severe COVID-19</jats:title> <jats:p> The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang <jats:italic>et al.</jats:italic> used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and III IFN immunity. They found enrichment of these genes in patients and conclude that genetics may determine the clinical course of the infection. Bastard <jats:italic>et al.</jats:italic> identified individuals with high titers of neutralizing autoantibodies against type I IFN-α2 and IFN-ω in about 10% of patients with severe COVID-19 pneumonia. These autoantibodies were not found either in infected people who were asymptomatic or had milder phenotype or in healthy individuals. Together, these studies identify a means by which individuals at highest risk of life-threatening COVID-19 can be identified. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd4570">eabd4570</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd4585">eabd4585</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6515" page="404" related-article-type="in-this-issue" vol="370" xlink:href="10.1126/science.abe7591">404</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Saving the poor and vulnerable
Ian L. Boyd
<jats:p>Right now, warm surface water is moving into the western Pacific Ocean in the form of a “La Niña.” It is a sentinel for a complex set of connections that drive weather patterns from the Horn of Africa to Botswana and normally presages drought in East Africa. This event soon will be ringing alarm bells within the World Food Programme (WFP). Even as this United Nations–led agency celebrates its well-deserved award of the 2020 Nobel Peace Prize, the relentless challenge of preventing hunger marches on.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 383-383
Science, politics, and public health
William Roper
<jats:p>There is an idea on the part of scientists that politics is dirty, and a companion idea on the part of politicians that science, by its continual qualifications and revisions, is, if not irrelevant, then at least out of touch with the constraints of a democracy: What seems optimal from the perspective of science may be impossible to implement in the political arena.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 385-385
News at a glance
<jats:p>A roundup of weekly science policy and related news.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 386-387
Global trial eliminates drugs, pivots to new ones
Kai Kupferschmidt
<jats:p>Definitive results on remdesivir and interferon demonstrate power of massive WHO study.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 388-389