Catálogo de publicaciones - revistas

<jats:title>The genomics of human development</jats:title> <jats:p> Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples. Cao <jats:italic>et al.</jats:italic> focus on measurements of RNA in broadly distributed cell types and provide insights into organ specificity. Domcke <jats:italic>et al.</jats:italic> examined the chromatin accessibility of cells from these organs and identify the regulatory elements that regulate gene expression. Together, these analyses generate comprehensive atlases of early human development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba7721">eaba7721</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba7612">eaba7612</jats:related-article> </jats:p>

<jats:p>An uncomfortable question has poked out from the chaos of the coronavirus disease 2019 (COVID-19) crisis—why does health inequity still persist in the United States? American people of color have been disproportionately affected by the pandemic. This, sadly, is no surprise because socioeconomic conditions, health care access challenges, and distrust in health care systems have historically prevented people of color from having healthier lives. As infections and deaths from COVID-19 continue to increase, effective treatments and vaccines are anxiously expected to become available soon. Unfortunately, less attention is being paid to questions about their equitable distribution and uptake. This only contributes to the suspicion felt by minority groups in the United States—particularly people of color—of the medical community. This barrier must come down. Every level of the health enterprise should pledge to reclaim the trust of all populations that is demanded by its professional oaths and missions.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Pioneering RNA candidate seems to work well, although its makers revealed scant data.</jats:p>

<jats:p>But president-elect has vowed to flex executive power.</jats:p>

<jats:p>President-elect vows "bedrock of science" will drive his administration's response to worsening U.S. crisis.</jats:p>

<jats:p>Sabin's oral vaccine has itself become a source of polio outbreaks. A modern, stabler version may reduce the risk.</jats:p>

<jats:p>Kerala health minister K. K. Shailaja has fought the pandemic with preparation, calm, and compassion.</jats:p>

<jats:p>Mass culling ordered after discovery of mutations that may affect vaccine efficacy.</jats:p>

<jats:p>Orbiters spy potential ongoing planetary "death spiral."</jats:p>