Catálogo de publicaciones - revistas

<jats:title>Precision therapy for immune tolerance</jats:title> <jats:p> Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes. Current treatments can cause systemic immune suppression and side effects such as increased risk of infections. Krienke <jats:italic>et al.</jats:italic> designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigens. In mouse models of MS, the vaccine delayed the onset and reduced the severity of established disease without showing overt symptoms of general immune suppression. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6525" page="145" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.aay3638">145</jats:related-article> </jats:p>

<jats:title>Social transmission of pain and relief</jats:title> <jats:p> In mice, both pain and fear can be transferred by short social contact from one animal to a bystander. Neurons in a brain region called the anterior cingulate cortex in the bystander animal mediate these transfers. However, the specific anterior cingulate projections involved in such empathy-related behaviors are unknown. Smith <jats:italic>et al.</jats:italic> found that projections from the anterior cingulate cortex to the nucleus accumbens are necessary for the social transfer of pain in mice (see the Perspective by Klein and Gogolla). Fear, however, was mediated by projections from the anterior cingulate cortex to the basolateral amygdala. Interestingly, in animals with pain, analgesia can also be transferred socially. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6525" page="153" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abe3040">153</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6525" page="122" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf5940">122</jats:related-article> </jats:p>