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Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

Brain disease and network reorganization

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 688.3-689

Elucidating synapse loss in MS

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 688.4-689

A dynamic quantum memory

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 688.5-689

The role of prevention

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 688.6-689

A close look into a very thin magnet

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 688.7-689

The role of officer race and gender in police-civilian interactions in Chicago

Bocar A. BaORCID; Dean KnoxORCID; Jonathan MummoloORCID; Roman RiveraORCID

<jats:title>Diversity in policing</jats:title> <jats:p> In the wake of high-profile police shootings of Black Americans, it is important to know whether the race and gender of officers and civilians affect their interactions. Ba <jats:italic>et al.</jats:italic> overcame previous data constraints and found that Hispanic and Black officers make far fewer stops and arrests and use force less than white officers, especially against Black civilians. These differences are largest in majority-Black neighborhoods in the city of Chicago (see the Perspective by Goff). Female officers also use less force than male officers. These effects are supportive of the efficacy of increasing diversity in police forces. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="696" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abd8694">696</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="677" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf4518">677</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 696-702

Catalytic asymmetric and stereodivergent oligonucleotide synthesis

Aaron L. FeatherstonORCID; Yongseok KwonORCID; Matthew M. PompeoORCID; Oliver D. Engl; David K. LeahyORCID; Scott J. MillerORCID

<jats:title>A P catalyst for stereogenic P(III)</jats:title> <jats:p> Phosphodiesters, the key linkage in DNA, RNA, and bioactive oligonucleotide and cyclic nucleotides, are typically synthesized from phosphoramidite precursors. Phosphorothioate linkages, which are more stable, can also be produced this way but have the complication of chirality at the P center, which is synthetically problematic, especially for multiple linkages. Featherston <jats:italic>et al.</jats:italic> found that two different chiral phosphoric acid catalysts provide stereodivergent synthesis of a stereogenic phosphite intermediate that can be oxidatively modified to the desired stereopure nucleotide derivative. They used this approach in the synthesis of a phosphorothioate derivative of the cyclic dinucleotide 2′,3′-cyclic guanosine monophosphate adenosine monophosphate, which is an important human immune signaling molecule. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6530" page="702" related-article-type="in-this-issue" vol="371">702</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 702-707

Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK

Louis du PlessisORCID; John T. McCroneORCID; Alexander E. ZarebskiORCID; Verity HillORCID; Christopher RuisORCID; Bernardo GutierrezORCID; Jayna RaghwaniORCID; Jordan AshworthORCID; Rachel ColquhounORCID; Thomas R. ConnorORCID; Nuno R. FariaORCID; Ben JacksonORCID; Nicholas J. LomanORCID; Áine O’TooleORCID; Samuel M. NichollsORCID; Kris V. ParagORCID; Emily ScherORCID; Tetyana I. Vasylyeva; Erik M. VolzORCID; Alexander WattsORCID; Isaac I. Bogoch; Kamran KhanORCID; David M. AanensenORCID; Moritz U. G. KraemerORCID; Andrew RambautORCID; Oliver G. PybusORCID;

<jats:title>Lineage dynamics</jats:title> <jats:p> The scale of genome-sequencing efforts for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unprecedented. The United Kingdom has contributed more than 26,000 sequences to this effort. This volume of data allowed du Plessis <jats:italic>et al.</jats:italic> to develop a detailed picture of the influxes of virus reaching U.K. shores as the pandemic developed during the first months of 2020 (see the Perspective by Nelson). Before lockdown, high travel volumes and few restrictions on international travel allowed more than 1000 lineages to become established. This accelerated local epidemic growth and exceeded contact tracing capacity. The authors were able to quantify the abundance, size distribution, and spatial range of the lineages that were transmitted. Transmission was highly heterogeneous, favoring some lineages that became widespread and subsequently harder to eliminate. This dire history indicates that rapid or even preemptive responses should have been used as they were elsewhere where containment was successful. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="708" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf2946">708</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="680" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg2297">680</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 708-712

A massive stellar bulge in a regularly rotating galaxy 1.2 billion years after the Big Bang

Federico LelliORCID; Enrico M. Di TeodoroORCID; Filippo FraternaliORCID; Allison W. S. ManORCID; Zhi-Yu ZhangORCID; Carlos De BreuckORCID; Timothy A. DavisORCID; Roberto MaiolinoORCID

<jats:title>Early assembly of a galaxy disk and bulge</jats:title> <jats:p> Galaxy formation in the early Universe is thought to have been a chaotic process, producing disturbed and asymmetric galaxy morphologies. Over billions of years, galaxies dynamically relaxed to form stable morphological features. Lelli <jats:italic>et al.</jats:italic> observed a distant galaxy at a redshift when the Universe was 1.2 billion years old (see the Perspective by Wardlow). They used gas and dust emission to measure its kinematics, and then modeled the mass distribution within the galaxy. The authors found that the galaxy contains a massive stellar bulge and a regularly rotating disk, features that models predict take billions of years to form. These results indicate that galaxy evolution is a more rapid process than previously thought. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="713" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abc1893">713</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="674" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg2907">674</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 713-716

Two-dimensional superconductivity and anisotropic transport at KTaO 3 (111) interfaces

Changjiang LiuORCID; Xi YanORCID; Dafei JinORCID; Yang MaORCID; Haw-Wen Hsiao; Yulin Lin; Terence M. Bretz-Sullivan; Xianjing ZhouORCID; John Pearson; Brandon FisherORCID; J. Samuel Jiang; Wei HanORCID; Jian-Min ZuoORCID; Jianguo WenORCID; Dillon D. FongORCID; Jirong SunORCID; Hua ZhouORCID; Anand BhattacharyaORCID

<jats:title>A superconducting interface</jats:title> <jats:p> Interfaces between materials can harbor quantum states that belong to neither of the materials. A classic example is the superconducting interface between two insulating oxides, LaAlO <jats:sub>3</jats:sub> and SrTiO <jats:sub>3</jats:sub> , with a critical temperature of around 200 millikelvin. Liu <jats:italic>et al.</jats:italic> observed superconductivity at a different interface—formed between KTaO <jats:sub>3</jats:sub> as a substrate and an overlayer of either EuO or LaAlO <jats:sub>3</jats:sub> —at a considerably higher temperature of about 2 kelvin. Transport measurements displayed anisotropy, which may indicate an unusual superconducting state. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6530" page="716" related-article-type="in-this-issue" vol="371">716</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 716-721