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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

naturales

Ciencias naturales

Tabla de contenidos

doi: 10.1126/science.2021.371.6531.twil

Editors' Choice

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794-795

doi: 10.1126/science.371.6531.794-a

Free trade between species

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.1-794

doi: 10.1126/science.371.6531.794-b

Cagey hydrosilylation

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.2-795

doi: 10.1126/science.371.6531.794-c

Stem cells relieve pressure

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.3-795

doi: 10.1126/science.371.6531.794-d

Wash in, wash out, repeat

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.4-795

doi: 10.1126/science.371.6531.794-e

A six-planet system with resonant orbits

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.5-795

doi: 10.1126/science.371.6531.794-f

A role for cholesterol in Ebola virus

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.6-795

doi: 10.1126/science.371.6531.794-g

Moving genes through parasitism

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 794.7-795

doi: 10.1126/science.abf5972

Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity

Travis R. BlumORCID; Hao LiuORCID; Michael S. PackerORCID; Xiaozhe XiongORCID; Pyung-Gang LeeORCID; Sicai ZhangORCID; Michelle RichterORCID; George MinasovORCID; Karla J. F. SatchellORCID; Min DongORCID; David R. LiuORCID

<jats:title>Moving targets of neurotoxins</jats:title> <jats:p> Proteases that cleave protein targets at specific sequences control many biological functions. The ability to reprogram proteases to cleave new sequences of our choosing would enable new therapeutic and biotechnological applications. Blum <jats:italic>et al.</jats:italic> report a laboratory evolution method to rapidly evolve proteases that cut new protein sequences and lose their ability to cut nontarget sequences (see the Perspective by Stenmark). Using this method, they evolved botulinum neurotoxin proteases, an important class of enzymes used in patients, to selectively cleave new targets, including a protein unrelated to those natively cleaved by these proteases. This work establishes a powerful approach to generate proteases with tailor-made specificities. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6531" page="803" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf5972">803</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6531" page="782" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg3535">782</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 803-810

doi: 10.1126/science.abb8677

A global environmental crisis 42,000 years ago

Alan CooperORCID; Chris S. M. TurneyORCID; Jonathan PalmerORCID; Alan HoggORCID; Matt McGloneORCID; Janet WilmshurstORCID; Andrew M. LorreyORCID; Timothy J. HeatonORCID; James M. RussellORCID; Ken McCrackenORCID; Julien G. AnetORCID; Eugene RozanovORCID; Marina FriedelORCID; Ivo SuterORCID; Thomas PeterORCID; Raimund MuschelerORCID; Florian AdolphiORCID; Anthony DossetoORCID; J. Tyler FaithORCID; Pavla FenwickORCID; Christopher J. FogwillORCID; Konrad HughenORCID; Mathew LipsonORCID; Jiabo LiuORCID; Norbert NowaczykORCID; Eleanor Rainsley; Christopher Bronk RamseyORCID; Paolo SebastianelliORCID; Yassine SouilmiORCID; Janelle StevensonORCID; Zoë ThomasORCID; Raymond ToblerORCID; Roland ZechORCID

<jats:title>Reversing the field</jats:title> <jats:p> Do terrestrial geomagnetic field reversals have an effect on Earth's climate? Cooper <jats:italic>et al.</jats:italic> created a precisely dated radiocarbon record around the time of the Laschamps geomagnetic reversal about 41,000 years ago from the rings of New Zealand swamp kauri trees. This record reveals a substantial increase in the carbon-14 content of the atmosphere culminating during the period of weakening magnetic field strength preceding the polarity switch. The authors modeled the consequences of this event and concluded that the geomagnetic field minimum caused substantial changes in atmospheric ozone concentration that drove synchronous global climate and environmental shifts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6531" page="811" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abb8677">811</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 811-818