Catálogo de publicaciones - revistas

<jats:title>Alligator Breath</jats:title> <jats:p> Birds have a unidirectional system of airflow within their lungs that has been attributed to the peculiarities of flight. However, <jats:bold>Farmer and Sanders</jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="338" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1180219">338</jats:related-article> ) provide evidence that this unidirectional and more or less continuous flow of air also occurs through parts of the alligator lung; in contrast to the tidal, biphasic system in mammals. By analyzing lung and tracheal structures, the similarities of the alligator lungs were compared with those of birds. The data suggest that the unusual properties of bird lungs originated before the divergence of the alligator line from the dinosaur or avian line. </jats:p>

<jats:title>Integrin G Protein</jats:title> <jats:p> Adhesion molecules, known as integrins, are found on the surface of cells. When integrins adhere to components of the extracellular matrix, they act as receptors and initiate signaling events within the cell. <jats:bold> Gong <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="340" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1174779">340</jats:related-article> ) show that they do so in part by partnering with a signal-transducing protein called Gα <jats:sub>13</jats:sub> . Such α subunits of heterotrimeric guanine nucleotide-binding proteins are well known for transducing signals from the large class of G protein–coupled receptors, but were not known to work with integrins. Gα <jats:sub>13</jats:sub> appears to interact directly with the integrin α <jats:sub>IIb</jats:sub> β <jats:sub>3</jats:sub> and to transmit signals that regulate cell spreading. </jats:p>

<jats:title>Parasitoid Wasp Genomes</jats:title> <jats:p> Parasitoid wasps, which prey on and reproduce in host insect species, play important roles in plant herbivore interactions, and may provide valuable tools in the biological control of pest species. <jats:bold> The <jats:italic>Nasonia</jats:italic> Genome Working Group </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="343" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1178028">343</jats:related-article> ; see the news story by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="5963" page="260" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.2010.327.5963.327_260">Pennisi</jats:related-article> </jats:bold> ) presents the genome of three very closely related species: <jats:italic>Nasonia vitripennis, N. giraulti</jats:italic> , and <jats:italic>N. longicornis</jats:italic> . The findings document rapid evolution between a host and endosymbiont that can cause nuclear-cytoplasmic incompatibilities that may affect speciation. </jats:p>

<jats:title>Behavioral Profiling</jats:title> <jats:p> The complexity of the brain makes it difficult to predict how a drug will affect behavior without direct testing in live animals. <jats:bold> Rihel <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="348" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1183090">348</jats:related-article> ) developed a high-throughput assay to assess the effects of thousands of drugs on sleep/wake behaviors of zebrafish larvae. The data set reveals a broad conservation of zebrafish and mammalian sleep/wake pharmacology and identifies pathways that regulate sleep. Moreover, the biological targets of poorly characterized small molecules can be predicted by matching their behavioral profiles to those of well-known drugs. Thus, behavioral profiling in zebrafish offers a cost-effective way to characterize neuroactive drugs and to predict biological targets of novel compounds. </jats:p>

<jats:p>The show includes a carbon capture catalyst, parasitoid wasp diversity, innate immunity, and more.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>