Catálogo de publicaciones - revistas

<jats:title> Mapping <jats:italic>Hydra</jats:italic> development cell by cell </jats:title> <jats:p> <jats:italic>Hydra</jats:italic> continually renews all cells in its body using three stem cell populations. This feature of <jats:italic>Hydra</jats:italic> allowed Siebert <jats:italic>et al.</jats:italic> to identify the transcriptional signatures of stem cells, progenitors, and terminally differentiated cells using single-cell RNA sequencing of adult <jats:italic>Hydra</jats:italic> (see the Perspective by Reddien). From these data, they built differentiation trajectories for all cell lineages, identified gene modules expressed along these trajectories, and identified putative regulators of genes within these modules. In addition, they identified candidate markers for elusive cell populations (such as multipotent stem cells and germline stem cells) and built a molecular map of the nervous system. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="eaav9314" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aav9314">eaav9314</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="314" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay3660">314</jats:related-article> </jats:p>

<jats:title>T cells help keep you lean</jats:title> <jats:p> The gut microbiota is a critical factor regulating mammalian metabolism. The host immune system, in turn, can shape the microbiome, in part via immunoglobulin A (IgA) antibodies. Petersen <jats:italic>et al.</jats:italic> report that mice defective in T follicular helper cell development and gut IgA production show hallmarks of metabolic syndrome with age (see the Perspective by Wang and Hooper). These mice gain more weight, accumulate more fat, and show greater insulin resistance compared with controls. IgA in these mice inappropriately targets Clostridia species and allows for the outgrowth of <jats:italic>Desulfovibrio.</jats:italic> Clostridia suppress and <jats:italic>Desulfovibrio</jats:italic> enhance host lipid absorption by modulating CD36 expression. A better understanding of the microbial products that modulate lipid absorption may open the door to future therapies for obesity and metabolic disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="eaat9351" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aat9351">eaat9351</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6451" page="316" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay2057">316</jats:related-article> </jats:p>

<jats:p>Last week, my colleagues and I went to the Palacio Nacional in Mexico City to deliver a petition signed by over 11,000 researchers in protest of the government's dismantling of science. One year ago, Mexico elected Andrés Manuel López Obrador as its new president. Many researchers voted for him, attracted by a campaign pledge to end corruption and violence and to promote science and education. Sadly, his actions have made things worse for science (see the News story on page 305). This cannot go on. Addressing poverty and corruption are not in opposition to social and economic investment in science and technology.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Strict new rules and prison sentences for biopiracy could stifle international research.</jats:p>

<jats:p>Andrés Manuel López Obrador has slashed support for institutes and suggested some scientists are corrupt.</jats:p>