Catálogo de publicaciones - revistas

<jats:p> Landis <jats:italic>et al</jats:italic> . claim in their comment that Ca does not bind like a transition metal in Ca(CO) <jats:sub>8</jats:sub> . We reject their statement, which is based on a misconception of bonding models and misleading application and interpretation of quantum chemical methods for analyzing chemical bonds. </jats:p>

<jats:title>Pairing prediction and robotic synthesis</jats:title> <jats:p> Progress in automated synthesis of organic compounds has been proceeding along parallel tracks. One goal is algorithmic prediction of viable routes to a desired compound; the other is implementation of a known reaction sequence on a platform that needs little to no human intervention. Coley <jats:italic>et al.</jats:italic> now report preliminary integration of these two protocols. They paired a retrosynthesis prediction algorithm with a robotically reconfigurable flow apparatus. Human intervention was still required to supplement the predictor with practical considerations such as solvent choice and precise stoichiometry, although predictions should improve as accessible data accumulate for training. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax1566">eaax1566</jats:related-article> </jats:p>

<jats:title>Brain circuit visualization and manipulation</jats:title> <jats:p> How are behaviorally relevant representations of the outside world initiated and manifested in the mammalian brain? Marshel <jats:italic>et al.</jats:italic> combined a channelrhodopsin with an improved holographic stimulation technique to examine activity in the mouse visual cortex, including its deep layers. Optogenetic stimulation of neurons previously activated by natural visual stimuli recreated the original activity and behavior. Neuronal population activity typically propagated from cortical layer 2/3 to layer 5 rather than in the reverse direction. Stimulation of a larger number of cells was required to initiate activity in layer 2/3 than in layer 5. This indicates differences in ensemble coding between the two layers. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw5202">eaaw5202</jats:related-article> </jats:p>

<jats:p> Wu <jats:italic>et al</jats:italic> . (Reports, 31 August 2018, p. 912) claim that recently characterized octacarbonyls of Ca, Sr, and Ba mimic the classical Dewar-Chatt-Duncanson bonding motif of transition metals. This claim, which contradicts known chemistry and computed electron density distributions, originates in the assumption of a flawed reference state for energy decomposition analyses. </jats:p>

<jats:p>Can science help take the partisanship out of politics? To some extent, that was the question the U.S. Supreme Court confronted in this year's blockbuster partisan gerrymandering case. The Court answered “no” and, by doing so, delivered an object lesson in the limits of math and science to settle the most political of constitutional questions.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>