Catálogo de publicaciones - revistas

<jats:title>The architecture of the RSC complex</jats:title> <jats:p> RSC is a Snf2-family chromatin remodeler complex that controls the promoter architecture of most of the genes in yeast. Using single-particle cryo–electron microscopy, Ye <jats:italic>et al.</jats:italic> determined the structure of RSC bound to the nucleosome. The structure reveals the modular architecture of RSC, shows how RSC engages the nucleosome, and explains the remodeling directionality. RSC shows strong similarities to homologous human complexes that are frequently mutated in cancers, and this structure provides valuable information for understanding these systems. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6467" page="838" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aay0033">838</jats:related-article> </jats:p>

<jats:title>Tuning stress protects cognition</jats:title> <jats:p> Down syndrome (DS) is a chromosomal disorder that occurs when a person has an extra copy of chromosome 21. DS causes intellectual disabilities, among other health issues, but little is known about the mechanisms underlying the memory deficits in DS. Zhu <jats:italic>et al.</jats:italic> used a multidisciplinary approach to show that a defect in integrated stress response, a conserved pathway that controls protein homeostasis, can explain the cognitive and neuronal deficits in a mouse model of DS (see the Perspective by Halliday and Mallucci). These insights into the biological basis underlying DS could potentially help in the design of treatments for this condition. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6467" page="843" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw5185">843</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6467" page="797" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz7128">797</jats:related-article> </jats:p>

<jats:title>Nanocage-chain fuel cell catalysts</jats:title> <jats:p> The expense and scarcity of platinum has driven efforts to improve oxygen-reduction catalysts in proton-exchange membrane fuel cells. Tian <jats:italic>et al.</jats:italic> synthesized chains of platinum-nickel alloy nanospheres connected by necking regions. These structures can be etched to form nanocages with platinum-rich surfaces that are highly active for oxygen reduction. In fuel cells running on air and hydrogen, these catalysts operated for at least 180 hours. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6467" page="850" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw7493">850</jats:related-article> </jats:p>