Catálogo de publicaciones - revistas

<jats:title>Pitching cGAMP as a vaccine strategy</jats:title> <jats:p> One strategy to address the variable effectiveness of many influenza vaccines is to induce antiviral resident memory T cells, which can mediate cross-protection against multiple substrains (heterosubtypic immunity). Unfortunately, such vaccines typically use attenuated active viruses, which may be unsafe for certain populations. Wang <jats:italic>et al.</jats:italic> report a vaccine using an inactivated virus that effectively induced heterosubtypic immunity in both mice and ferrets (see the Perspective by Herold and Sander). They coadministered the virus with 2′,3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), a potent activator of the innate immune system, encapsulated in pulmonary surfactant–biomimetic liposomes. This adjuvant was taken up by alveolar epithelial cells, whose activation resulted in effective antiviral T cell and humoral immune responses without accompanying immunopathology. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau0810">eaau0810</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6480" page="852" related-article-type="in-this-issue" vol="367" xlink:href="10.1126/science.aba2754">852</jats:related-article> </jats:p>

<jats:title>Thymus development, cell by cell</jats:title> <jats:p> The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a full immune complement that contains the necessary variation to protect us from a variety of pathogens. By performing single-cell RNA sequencing on more than 250,000 cells, Park <jats:italic>et al.</jats:italic> examined the changes that occur in the thymus over the course of a human life. They found that development occurs in a coordinated manner among immune cells and with their developmental microenvironment. These data allowed for the creation of models of how T cells with different specific immune functions develop in humans. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay3224">eaay3224</jats:related-article> </jats:p>

<jats:title>The pervasive power of mycorrhizas</jats:title> <jats:p> Associations between plants and symbiotic fungi—mycorrhizas—are ubiquitous in plant communities. Tedersoo <jats:italic>et al.</jats:italic> review recent developments in mycorrhizal research, revealing the complex and pervasive nature of this largely invisible interaction. Complex networks of mycorrhizal hyphae connect the root systems of individual plants, regulating nutrient flow and competitive interactions between and within plant species, controlling seedling establishment, and ultimately influencing all aspects of plant community ecology and coexistence. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba1223">eaba1223</jats:related-article> </jats:p>

<jats:p>During my 15 years riding on the administrative Tilt-a-Whirl, I was a no-show at scientific conferences. Prior to that, during my faculty years, my go-to conferences were the national American Chemical Society meetings and Gordon Research Conferences—especially Metals in Biology, which is in January in Ventura, California. This past January, I went back to Ventura after a 15-year hiatus. A lot of things struck me about how things have changed—mostly for the better—and how some things have stayed the same. One thing that is increasingly on peoples' minds is the future of scientific meetings.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Experiments are halted as China remains locked down; many conferences are canceled.</jats:p>

<jats:p>Questions arise about the work of researcher Jeff Leach, known for studies of Hadza hunter-gatherers in Tanzania.</jats:p>