Catálogo de publicaciones - revistas

<jats:title>Commencing oogenesis</jats:title> <jats:p> In mice, embryonic stem cells and induced pluripotent stem cells have been shown to differentiate into primordial germ cell–like cells that can give rise to functional oocytes. In this system, Nagaoka <jats:italic>et al.</jats:italic> identified the gene <jats:italic>Zglp1</jats:italic> as a necessary and sufficient factor for conferring the oogenic fate to sexually undetermined germ cells. As a downstream effector of bone morphogenetic protein signaling, conserved transcriptional regulator ZGLP1 activates the oogenic program repressed by Polycomb activities, whereas retinoic acid signaling assists the maturation of such activation and also the repression of the primordial germ cell program. This study thus refines our understanding of mammalian oogenic fate determination. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw4115">eaaw4115</jats:related-article> </jats:p>

<jats:title>Mapping the mammalian brain</jats:title> <jats:p> The diverse physiology of the brain is reflected in its complex organization at regional, cellular, and subcellular levels. Sjöstedt <jats:italic>et al.</jats:italic> combined data—both newly acquired and from other large-scale brain mapping projects—from transcriptomics, single-cell genomics, in situ hybridization, and antibody-based protein profiling to map the molecular profiles in human, pig, and mouse brain. The analysis is consistent with a conserved basic brain architecture during mammalian evolution, but it does show differences in regional gene expression profiles. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay5947">eaay5947</jats:related-article> </jats:p>

<jats:p>Biological research is profoundly valuable but can carry profound risks. The coronavirus outbreak reminds us of our vulnerability to biological threats and that research on pathogens is vital to threat mitigation. But such research can lead to catastrophic safety and security incidents. A global proliferation of tools and capabilities, driven by economic and national security interests, is also generating risks that fall outside current governance frameworks. We must learn to manage risks as quickly as we learn to manipulate life, but it remains unclear how well we are doing. One opportunity to learn is found in a new charge to the U.S. National Science Advisory Board for Biosecurity (NSABB), which reconvened in January after a 2-year hiatus, to assess the effectiveness of U.S. dual-use research oversight policies. To meet the charge and suggest improvements, the NSABB must address a neglected need for an evidence base for adaptive risk management. Building this evidence base will require revisiting success criteria, creating data infrastructures, and fostering adaptive policies and testbeds.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Rapid decline in cases is real, expert mission concludes—but it came at a high cost.</jats:p>

<jats:p>A new theory tries to explain enigmatic "blocks" that bring heat waves and drought.</jats:p>

<jats:p>Random outbreak at research center points to tilapia variants that resist the deadly emerging tilapia lake virus.</jats:p>