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which prevent the occurrence of chronic diseases through their impacts on the gastrointestinal; immune; bioavailability; and the modulation of human nutrition.; and nervous systems. Further bioactive peptide discoveries are essential for maintaining human health and commercial development in the area of functional foods and nutraceuticals. This Special Issue covers a wide range of research topics specifically on food-derived bioactive proteins and peptides including the in-vitro and in-vivo evaluation of biological activities; the effect on chronic diseases; Food-derived bioactive peptides or dietary peptides are increasingly becoming recognized as major food compounds for human health promotion; intestinal absorption; cardiovascular; bio-accessibility