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Estudio histofisilógico del efecto de un agente inmunomodulador intramamario en la involución de la glándula mamaria bovina

Bibiana Elisabet Dallard Luis Fernando Calvinho Cristina Inés Bogni Eduardo Juan Gimeno Ileana Sofia Malan Borel

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Resumen/Descripción – provisto por el repositorio digital
Agents that increase natural protective mechanisms have been proposed for prevention and treatment of intramammary infections. Staphylococcus aureus is a major pathogen causing primarily sub clinical chronic mastitis, which responds poorly to antibiotic therapy. The objectives of this study were to describe the effects of a single intramammary infusion of a lipopolysaccharide-based biological response modifier (BRM) on a) cellular proliferation, b) cellular death mechanisms, c) unspecific immune response, d) cellular infiltrating cells quantification and e) growth factors expression, in uninfected and S. aureus-infected bovine mammary glands during involution. In conclusion, BRM treatment in uninfected mammary glands induced macrophages infiltration, increased apoptogenic proteases staining and apoptosis of both epithelial and stromal mammary cells. On the other hand, BRM treatment in S. aureus-infected mammary glands induced an increase of TNF-alfa, infiltrating macrophages, pro-apoptotic proteins (Bax), apoptogenic proteases and apoptosis, neither causing deleterious effects on mammary tissue nor inhibiting mammary cell proliferation. In adition, presence of S. aureus IMI during mammary involution resulted in an increase in VEGF and IGF-I expression that was not affected by BRM treatment.
Palabras clave – provistas por el repositorio digital

Inmunomodulador; Glándula mamaria; Bovino; Staphylococcus aureus; Involución; Immunomodulator; Mammary gland; Bovine; Involution

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Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2007 Biblioteca Virtual de la Universidad Nacional del Litoral (SNRD) acceso abierto

Información

Tipo de recurso:

tesis

Idiomas de la publicación

  • español castellano

País de edición

Argentina

Fecha de publicación