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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
AAAS News and Notes
<jats:p> A monthly roundup of recent news and projects of <jats:italic>Science</jats:italic> 's publisher, the American Association for the Advancement of Science. </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1079-1080
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Peter Walter; David Ron
<jats:p>The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled proteins advance from the ER to the cell surface. To ascertain fidelity in protein folding, cells regulate the protein-folding capacity in the ER according to need. The ER responds to the burden of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways, collectively termed the unfolded protein response (UPR). Together, at least three mechanistically distinct branches of the UPR regulate the expression of numerous genes that maintain homeostasis in the ER or induce apoptosis if ER stress remains unmitigated. Recent advances shed light on mechanistic complexities and on the role of the UPR in numerous diseases.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1081-1086
Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
Melanie H. Smith; Hidde L. Ploegh; Jonathan S. Weissman
<jats:p>Some nascent proteins that fold within the endoplasmic reticulum (ER) never reach their native state. Misfolded proteins are removed from the folding machinery, dislocated from the ER into the cytosol, and degraded in a series of pathways collectively referred to as ER-associated degradation (ERAD). Distinct ERAD pathways centered on different E3 ubiquitin ligases survey the range of potential substrates. We now know many of the components of the ERAD machinery and pathways used to detect substrates and target them for degradation. Much less is known about the features used to identify terminally misfolded conformations and the broader role of these pathways in regulating protein half-lives.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1086-1090
The Cambrian Conundrum: Early Divergence and Later Ecological Success in the Early History of Animals
Douglas H. Erwin; Marc Laflamme; Sarah M. Tweedt; Erik A. Sperling; Davide Pisani; Kevin J. Peterson
<jats:p>Major animal clades evolved tens of millions of years before the widespread appearance of animal fossils.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1091-1097
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
Robert Pejchal; Katie J. Doores; Laura M. Walker; Reza Khayat; Po-Ssu Huang; Sheng-Kai Wang; Robyn L. Stanfield; Jean-Philippe Julien; Alejandra Ramos; Max Crispin; Rafael Depetris; Umesh Katpally; Andre Marozsan; Albert Cupo; Sebastien Maloveste; Yan Liu; Ryan McBride; Yukishige Ito; Rogier W. Sanders; Cassandra Ogohara; James C. Paulson; Ten Feizi; Christopher N. Scanlan; Chi-Huey Wong; John P. Moore; William C. Olson; Andrew B. Ward; Pascal Poignard; William R. Schief; Dennis R. Burton; Ian A. Wilson
<jats:p>An HIV antibody achieves potency and breadth by binding simultaneously to two conserved glycans on the viral envelope protein.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1097-1103
A Cocoon of Freshly Accelerated Cosmic Rays Detected by Fermi in the Cygnus Superbubble
M. Ackermann; M. Ajello; A. Allafort; L. Baldini; J. Ballet; G. Barbiellini; D. Bastieri; A. Belfiore; R. Bellazzini; B. Berenji; R. D. Blandford; E. D. Bloom; E. Bonamente; A. W. Borgland; E. Bottacini; M. Brigida; P. Bruel; R. Buehler; S. Buson; G. A. Caliandro; R. A. Cameron; P. A. Caraveo; J. M. Casandjian; C. Cecchi; A. Chekhtman; C. C. Cheung; J. Chiang; S. Ciprini; R. Claus; J. Cohen-Tanugi; A. de Angelis; F. de Palma; C. D. Dermer; E. do Couto e Silva; P. S. Drell; D. Dumora; C. Favuzzi; S. J. Fegan; W. B. Focke; P. Fortin; Y. Fukazawa; P. Fusco; F. Gargano; S. Germani; N. Giglietto; F. Giordano; M. Giroletti; T. Glanzman; G. Godfrey; I. A. Grenier; L. Guillemot; S. Guiriec; D. Hadasch; Y. Hanabata; A. K. Harding; M. Hayashida; K. Hayashi; E. Hays; G. Jóhannesson; A. S. Johnson; T. Kamae; H. Katagiri; J. Kataoka; M. Kerr; J. Knödlseder; M. Kuss; J. Lande; L. Latronico; S.-H. Lee; F. Longo; F. Loparco; B. Lott; M. N. Lovellette; P. Lubrano; P. Martin; M. N. Mazziotta; J. E. McEnery; J. Mehault; P. F. Michelson; W. Mitthumsiri; T. Mizuno; C. Monte; M. E. Monzani; A. Morselli; I. V. Moskalenko; S. Murgia; M. Naumann-Godo; P. L. Nolan; J. P. Norris; E. Nuss; T. Ohsugi; A. Okumura; E. Orlando; J. F. Ormes; M. Ozaki; D. Paneque; D. Parent; M. Pesce-Rollins; M. Pierbattista; F. Piron; M. Pohl; D. Prokhorov; S. Rainò; R. Rando; M. Razzano; T. Reposeur; S. Ritz; P. M. Saz Parkinson; C. Sgrò; E. J. Siskind; P. D. Smith; P. Spinelli; A. W. Strong; H. Takahashi; T. Tanaka; J. G. Thayer; J. B. Thayer; D. J. Thompson; L. Tibaldo; D. F. Torres; G. Tosti; A. Tramacere; E. Troja; Y. Uchiyama; J. Vandenbroucke; V. Vasileiou; G. Vianello; V. Vitale; A. P. Waite; P. Wang; B. L. Winer; K. S. Wood; Z. Yang; S. Zimmer; S. Bontemps
<jats:p>Cosmic rays can be accelerated in the cavities carved by the stellar winds created by clusters of massive stars.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1103-1107
Fermi Detection of a Luminous γ-Ray Pulsar in a Globular Cluster
; P. C. C. Freire; A. A. Abdo; M. Ajello; A. Allafort; J. Ballet; G. Barbiellini; D. Bastieri; K. Bechtol; R. Bellazzini; R. D. Blandford; E. D. Bloom; E. Bonamente; A. W. Borgland; M. Brigida; P. Bruel; R. Buehler; S. Buson; G. A. Caliandro; R. A. Cameron; F. Camilo; P. A. Caraveo; C. Cecchi; Ö. Çelik; E. Charles; A. Chekhtman; C. C. Cheung; J. Chiang; S. Ciprini; R. Claus; I. Cognard; J. Cohen-Tanugi; L. R. Cominsky; F. de Palma; C. D. Dermer; E. do Couto e Silva; M. Dormody; P. S. Drell; R. Dubois; D. Dumora; C. M. Espinoza; C. Favuzzi; S. J. Fegan; E. C. Ferrara; W. B. Focke; P. Fortin; Y. Fukazawa; P. Fusco; F. Gargano; D. Gasparrini; N. Gehrels; S. Germani; N. Giglietto; F. Giordano; M. Giroletti; T. Glanzman; G. Godfrey; I. A. Grenier; M.-H. Grondin; J. E. Grove; L. Guillemot; S. Guiriec; D. Hadasch; A. K. Harding; G. Jóhannesson; A. S. Johnson; T. J. Johnson; S. Johnston; H. Katagiri; J. Kataoka; M. Keith; M. Kerr; J. Knödlseder; M. Kramer; M. Kuss; J. Lande; L. Latronico; S.-H. Lee; M. Lemoine-Goumard; F. Longo; F. Loparco; M. N. Lovellette; P. Lubrano; A. G. Lyne; R. N. Manchester; M. Marelli; M. N. Mazziotta; J. E. McEnery; P. F. Michelson; T. Mizuno; A. A. Moiseev; C. Monte; M. E. Monzani; A. Morselli; I. V. Moskalenko; S. Murgia; T. Nakamori; P. L. Nolan; J. P. Norris; E. Nuss; T. Ohsugi; A. Okumura; N. Omodei; E. Orlando; M. Ozaki; D. Paneque; D. Parent; M. Pesce-Rollins; M. Pierbattista; F. Piron; T. A. Porter; S. Rainò; S. M. Ransom; P. S. Ray; A. Reimer; O. Reimer; T. Reposeur; S. Ritz; R. W. Romani; M. Roth; H. F.-W. Sadrozinski; P. M. Saz Parkinson; C. Sgrò; R. Shannon; E. J. Siskind; D. A. Smith; P. D. Smith; P. Spinelli; B. W. Stappers; D. J. Suson; H. Takahashi; T. Tanaka; T. M. Tauris; J. B. Thayer; G. Theureau; D. J. Thompson; S. E. Thorsett; L. Tibaldo; D. F. Torres; G. Tosti; E. Troja; J. Vandenbroucke; A. Van Etten; V. Vasileiou; C. Venter; G. Vianello; N. Vilchez; V. Vitale; A. P. Waite; P. Wang; K. S. Wood; Z. Yang; M. Ziegler; S. Zimmer
<jats:p> Contrary to expectations, the <jats:bold>γ</jats:bold> -rays from a distant cluster of stars are dominated by emission from a single neutron star. </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1107-1110
A Homonuclear Molecule with a Permanent Electric Dipole Moment
W. Li; T. Pohl; J. M. Rost; Seth T. Rittenhouse; H. R. Sadeghpour; J. Nipper; B. Butscher; J. B. Balewski; V. Bendkowsky; R. Löw; T. Pfau
<jats:p>Two rubidium atoms, one in its ground state and the other with a highly excited electron, form a metastable polar molecule.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1110-1114
Discovery of an α-Amino C–H Arylation Reaction Using the Strategy of Accelerated Serendipity
Andrew McNally; Christopher K. Prier; David W. C. MacMillan
<jats:p>An unanticipated photocatalytic carbon-carbon bond-forming reaction emerged from screening many unusual reagent combinations.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1114-1117
Pelagic Fishing at 42,000 Years Before the Present and the Maritime Skills of Modern Humans
Sue O’Connor; Rintaro Ono; Chris Clarkson
<jats:p>Abundant fish remains from a shelter in East Timor imply that humans were fishing the deep sea by 43,000 years ago.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1117-1121