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<jats:p>Less than a year before a new edition of the diagnostic reference for psychiatric illnesses is to be released, the controversy it has generated continues.</jats:p>

<jats:p>The nature of the "dark energy" that is causing the expansion of the universe to accelerate is now perhaps the most profound mystery in cosmology and astrophysics. And it may remain forever so.</jats:p>

<jats:p>Astronomers still don't know what the unseen "dark matter" is that provides the gravity that holds the galaxies together, but they may soon be able to narrow in on its most basic properties.</jats:p>

<jats:p>Not only are astronomers unable to pin down dark energy and dark matter, but more than half of the "baryonic matter"—ordinary atoms and ions—remains unaccounted for.</jats:p>

<jats:p>Many details of what goes on inside a star when its fuel has been spent and it explodes into a giant fireball known as a supernova, as well as how that explosion unfolds, remain a mystery.</jats:p>

<jats:p>A few hundred million years after the big bang, most of the universe's matter turned into the light-transmitting ionized plasma that it remains today. What caused this cosmic reionization? No one is sure.</jats:p>

<jats:p>Data taken from detectors in the past few years have provided some clues to the origin of the highest energy cosmic rays but, as yet, no smoking gun.</jats:p>

<jats:p>Enigmas such as Mercury's makeup (mostly iron core, with a thin veneer of rock) and Uranus's skewed magnetic field continue to bedevil planetary scientists, and no tidy resolution is in sight.</jats:p>

<jats:p>How does heat dissipating from the sun's core out beyond the surface to its corona abruptly punch temperatures up by a factor of 200 and more?</jats:p>