Catálogo de publicaciones - revistas

<jats:title>Keeping Baby Safe</jats:title> <jats:p> Because half the genes from a developing fetus are inherited from the father, from the mother's perspective, a fetus is “foreign.” How, then, does the maternal immune system tolerate the fetus? <jats:bold> Nancy <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1317" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1220030">1317</jats:related-article> ) found that careful regulation of cellular recruitment signals allowed for fetal tolerance in mice. Although high numbers of T cells localized to the myometrium layer of the uterine wall in pregnant mice, very few T cells were found in the decidua, the uterine tissue that encapsulates the fetus and placenta. Thus, in pregnancy, regulation of immune cell localization may allow for organ-specific immune tolerance. </jats:p>

<jats:title>Protecting Against a Barrier Breach</jats:title> <jats:p> In order to coexist peacefully, a “firewall” exists that keeps the commensal bacteria that reside in our intestines and associated lymphoid tissue contained. Several diseases and infections, however, lead to a breach in this barrier, which leads to chronic inflammation and pathology. <jats:bold> Sonnenberg <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1321" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1222551">1321</jats:related-article> ) found that in mice, innate lymphoid cells (ILCs) are critically important for the anatomical containment of commensal bacteria in an interleukin-22 (IL-22)–dependent manner. ILC depletion or blockade of IL-22 led to loss of bacterial containment and systemic inflammation. </jats:p>

<jats:title>Establishing an Enteric Infection</jats:title> <jats:p> Complex and highly regulated interactions are required to keep the peace between the bacteria that reside in our gut and the immune system. How do pathogenic bacteria, such as the strains of <jats:italic>Escherichia coli</jats:italic> that cause gastroenteritis, get a foothold to establish an infection, and what is the role of resident bacteria in this process? <jats:bold> Kamada <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1325" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1222195">1325</jats:related-article> , published online 10 May; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6086" page="1238" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1223303">Sperandio</jats:related-article> </jats:bold> ) infected mice orally with <jats:italic>Citrobacter rodentium</jats:italic> and found that mice with normal commensal microflora, which were better able to contain the infection than mice that lacked the commensals, which were not able to clear the infection. </jats:p>

<jats:p>Photography has been a fundamental part of biology for more than a century, but a new generation of digital imaging technologies is revolutionizing the way life scientists capture and analyze visual data.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>The show includes harnessing biological hammers, respecting our microbial residents, the health implications of mass gatherings, and more.</jats:p>