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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

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doi: 10.1126/science.340.6131.499-c

Proteomics Meets Cellular Signaling: Exploring Post-translational Modifications by Mass Spectrometry

Vipin Suri; Cloud Paweletz; Chunaram Choudhary

<jats:p>Post-translational modifications (PTMs)â€”including phosphorylation, acetylation, and ubiquitinationâ€”are specific modifications that can alter the activity of an individual protein target. The cumulative effect of these small modifications is the regulation of large signaling pathways and networks within cells.</jats:p> <jats:p>Mass spectrometry is a powerful tool for the identification of individual PTMs during the investigation of signaling networks. A new approach using antibody-based peptide enrichment for a class of PTMs combined with tandem mass spectrometry has been successfully used for global identification of hundreds to thousands of PTMs within a sample. In this webinar, examples of how the technology was applied to each of these PTM classes will be described.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 499-499

doi: 10.1126/science.340.6131.499-a

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 499-499

doi: 10.1126/science.340.6131.499-b

Science Podcast: 26 April Show

<jats:p>Listen to stories on social networking in whales, a pulsar's affirmation of general relativity, monitoring TB in North Korea, and more.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 499-499

doi: 10.1126/science.340.6132.523-i