Catálogo de publicaciones - revistas

<jats:title>Newlywed Game?</jats:title> <jats:p> The extent to which our “gut” feelings influence our social interactions has been a matter of debate. Social psychologists have sometimes been criticized for their reliance on short-term analyses of undergraduates as test subjects. <jats:bold> McNulty <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6162" page="1119" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1243140">1119</jats:related-article> ) measured explicit and implicit attitudes of newlywed couples toward one another twice a year for 4 years. Over time, the implicit or unaware evaluations of the relationship predicted changes of marital satisfaction, whereas the explicit or conscious evaluations did not. </jats:p>

<jats:p>Next generation sequencing technologies have enabled a rapid expansion toward the understanding of inherited disorders, cancer biology, drug development, and treatment resistance. Exome sequencing has been increasingly and successfully applied in the clinical research setting for identifying common single nucleotide variants, copy number variations, and small insertions or deletions as well as rare de novo mutations that may explain Mendelian, complex, and rare genetic disorders. Recent advancement in rapid and low-cost exome sequencing make it an attractive alternative to traditional targeted gene panel sequencing for clinical research, while maintaining the possibility of discovering mutations in genes previously not associated with a disorder. Furthermore, the exome encompasses approximately 1% of the genome, yet contains approximately 85% of disease-causing mutations, making exome sequencing easier and cheaper than whole genome sequencing for identifying disease-causing variants in research.</jats:p> <jats:p>Researchers are now applying proband-father-mother (trio) exome sequencing to uncover variants that potentially either cause or modify the condition under study. In this webinar, the audience will learn about the current applications of exome sequencing in clinical research and its impact on the future of health care.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Listen to stories on the top children’s books of 2013, what newlyweds know about their prospects for happiness, authorship for sale in China, and more.</jats:p>

<jats:title>Light Turns the Array</jats:title> <jats:p> The organization of cortical microtubule arrays in higher plant cells is essential for organizing cell and tissue morphogenesis, but it is not clear how specific architectures are acquired and reconfigured in response to environmental cues. <jats:bold> Lindeboom <jats:italic>et al.</jats:italic> </jats:bold> ( <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1245533">10.1126/science.1245533</jats:related-article> , published online 7 November; see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6163" page="1180" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1248235"> <jats:bold>Roll-Mecak</jats:bold> </jats:related-article> ) used live-cell imaging and genetic studies to show that the microtubule-severing protein, katanin, plays a crucial role in reorienting cortical arrays from transverse to longitudinal in <jats:italic>Arabidopsis</jats:italic> seedlings in response to blue light perception. Katanin localized to microtubule intersections where, stimulated by blue light receptors, it preferentially catalyzed the severing of the newer microtubule. The microtubule “plus” end created by severing were observed to grow preferentially, effectively building a new population of microtubules orthogonal to the initial array. The net effect of this process steers the growing seedling toward light. </jats:p>

<jats:p>There is currently much interest in broad molecular profiling of single cells; a cell’s metabolome—its full complement of small-molecule metabolites—is a direct indicator of phenotypic diversity of single cells and a nearly immediate readout of how cells react to environmental influences. However, the metabolome is very difficult to measure at the single-cell level because of rapid metabolic dynamics, the structural diversity of the molecules, and the inability to amplify or tag small-molecule metabolites. Measurement techniques including mass spectrometry, capillary electrophoresis, and, to a lesser extent, optical spectroscopy and fluorescence detection have led to impressive advances in single-cell metabolomics. Even though none of these methodologies can currently measure the metabolome of a single cell completely, rapidly, and nondestructively, progress has been sufficient such that the field is witnessing a shift from feasibility studies to investigations that yield new biological insight. Particularly interesting fields of application are cancer biology, stem cell research, and monitoring of xenobiotics and drugs in tissue sections at the single-cell level.</jats:p>