Catálogo de publicaciones - revistas

<jats:title>Sourcing corrosive sewer sulfides</jats:title> <jats:p> Sewer systems are corroding at an alarming rate, costing governments billions of dollars to replace. Differences among water treatment systems make it difficult to track down the source of corrosive sulfide responsible for this damage. Pikaar <jats:italic>et al.</jats:italic> performed an extensive industry survey and sampling campaign across Australia (see the Perspective by Rauch and Kleidorfer). Aluminum sulfate added as a coagulant during drinking water treatment was the primary culprit in corroding sewer systems. Modifying this common treatment strategy to include sulfate-free coagulants could dramatically reduce sewer corrosion across the globe. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="812" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1251418">812</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="734" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1257988">734</jats:related-article> </jats:p>

<jats:title>Nerve cells displaying extra large spaces</jats:title> <jats:p> Rats use brain cells called “place” cells to figure out where they are. Rich <jats:italic>et al.</jats:italic> used mazes or tracks many meters long—the size of rats' ranges in the wild—to investigate how rats represent a very large environment or extended experience in their brain. As novel environments became larger and larger, the rats' brains recruited new place cells. However, no matter how large the environment became, some cells always remained silent, perhaps as a reserve for other environments yet to be visited. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="814" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255635">814</jats:related-article> </jats:p>

<jats:title>A breathtaking tale of sticky mucus</jats:title> <jats:p> Patients with cystic fibrosis have difficulty breathing because their airways are clogged with thick mucus. Does this mucus accumulate because there is a defect in the way it is produced? Or does it accumulate because of other disease features, such as dehydration or airway wall remodeling? Distinguishing between these possibilities is important for future drug development. In a study of piglets with cystic fibrosis, Hoegger <jats:italic>et al.</jats:italic> identify mucus production as the primary defect (see the Perspective by Wine). The airway glands of the piglets synthesized strands of mucus normally, but the strands were never released and stayed tethered to the gland ducts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="818" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255825">818</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="730" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1258493">730</jats:related-article> </jats:p>

<jats:title>Factor in oocyte assists reprogramming</jats:title> <jats:p> Unfertilized eggs contain components that can dedifferentiate other cells that have gone down the path toward a specific cell fate. Gonzalez-Muñoz <jats:italic>et al.</jats:italic> show that the protein-folding factor ASF1A facilitates this reprogramming event and it acts at a particular phase of germ cell division termed metaphase II. ASF1A helps turn differentiated cells such as human adult dermal fibroblasts into undifferentiated pluripotent stem cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="822" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1254745">822</jats:related-article> </jats:p>

<jats:title>Epigenetics direct transdifferentiation</jats:title> <jats:p> To make an entire animal, many and varied cell types form and interact. Some of these differentiated cells take a U-turn and can de-differentiate or transdifferentiate to another cell fate. Although relatively rare in nature, Zuryn <jats:italic>et al.</jats:italic> followed such a program in the tiny roundworm <jats:italic>Caenorhabditis elegans</jats:italic> , where a rectal cell–to–motor neuron conversion is seen. Transcription factors with conserved roles in cell plasticity and terminal fate selection partner up with specific histone-modifying enzymes in discrete steps to specify separate sequential phases of cell identity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="826" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255885">826</jats:related-article> </jats:p>

<jats:title>Toward an “artificial cell” on a chip</jats:title> <jats:p> Cell-free systems that reconstitute biochemical pathways have been critical for unraveling the inner workings of the cell. Karzbrun <jats:italic>et al.</jats:italic> created a highly miniaturized cell-free system on a silicon chip. A series of tiny linked compartments were fabricated on the chip, in which DNA-driven reactions occurred, with materials flowing into and diffusing between the compartments. The system recreated oscillating protein expression patterns and protein gradients, and provides a stepping stone to creating “artificial cells” on a chip. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6198" page="829" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255550">829</jats:related-article> </jats:p>

<jats:p>On this week's show: Parenting before conception and a news roundup.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>