Catálogo de publicaciones - revistas

<jats:title>Bringing in the agent of your own destruction</jats:title> <jats:p> Cells need mechanisms to detect and disable pathogens that infect them. Tam <jats:italic>et al.</jats:italic> now show that complement C3, a protein that binds to pathogens in the blood, can enter target cells together with the pathogen. Once inside the cell, the presence of C3 triggers both immune signaling and degradation of the internalized pathogen. The discovery of this pathway reveals that cells possess an early warning system of invasion that works against a diverse array of pathogens and does not require recognition of any specific pathogen molecules. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1256070">10.1126/science.1256070</jats:related-article> </jats:p>

<jats:p>The current crisis with the Ebola virus vividly illustrates the priority that must be given to infectious diseases because of their potentially devastating consequences to individuals and to society. Few would argue against the need for more research on Ebola and the expedited development of a cure; however, recent incidents in biocontainment laboratories and the proliferation of such facilities globally raise concerns about safety and have split the scientific community. Scientists who defend research on dangerous pathogens as vital to protecting populations are opposed by those who fear the potential devastation caused by the intentional or unintentional release of pathogens from the lab. Achieving a “culture of safety,” so often alluded to after recent lapses in biosafety procedures, demands adopting a “culture of responsibility” as well.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Italian probe depicts web of scandal, including illegal animal vaccines and deliberate outbreaks.</jats:p>

<jats:p>Eurasian “ghost lineage” contributed to most modern European genomes.</jats:p>

<jats:p>Modelers of infectious diseases strive to predict spread of the virus—and how to stop it.</jats:p>

<jats:p>Scientists are struggling to rein in the culprit: feral cats, aided by fire.</jats:p>

<jats:p>Japan's developmental biology powerhouse brought to knees by misconduct revelations.</jats:p>

<jats:p>Large volumes of fuel from crop wastes will soon start flowing in the U.S.—unless policymakers balk.</jats:p>