Catálogo de publicaciones - revistas

<jats:title>Keeping repressed genes repressed</jats:title> <jats:p> <jats:italic>Hox</jats:italic> genes confer positional identity to cells and tissues. Maintaining precise spatial patterns of <jats:italic>Hox</jats:italic> gene expression is vital during metazoan development. The transcriptional repressor CTCF is involved in the regulation of chromatin architecture. Narendra <jats:italic>et al.</jats:italic> show that a CTCF protein binding site insulates regions of active and repressed <jats:italic>Hox</jats:italic> gene expression from each other. This protects heterochromatin containing repressed <jats:italic>Hox</jats:italic> genes from the encroaching spread of active chromatin. The CTCF protein appears to organize the active and repressed chromatin regions into distinct architectural domains. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6225" page="1017" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1262088">1017</jats:related-article> </jats:p>

<jats:p>On this week's show: sexual traits and malaria transmission in mosquitoes, and a roundup of daily news stories.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Western blots have been around for over 30 years and are used in practically every life science laboratory. Equally well known, but often not satisfactorily addressed, are the challenges of reproducibility and the difficulty in obtaining accurate quantitative data and reliable results from Western blot experiments. In this webinar we will explore the issues of reproducibility in immunoblotting in more depth and discuss how to obtain higher quality data, with a focus on those key factors necessary to create consistent, quantifiable results. Our expert panelists will discuss new methodologies and recent advances that have allowed the coefficients of variation (CVs) for Western blotting experiments to be reduced below 10% (currently, CVs are often in the 35%–45% range).</jats:p>

<jats:p>A decade ago, the "sink or swim" culture was widespread in research. But academic institutions across the United States and Europe are now investing resources in helping young researchers gain the skills they need for climbing the career ladder. Top on the list are leadership skills, whether for conflict management, handling finances, or negotiating intellectual property rights in an international consortium, these are highly rated assets that can help researchers advance to senior roles. Here's a look at some of the most established leadership programs that hold alumni who are leaping ahead as a result of the training.</jats:p>