Catálogo de publicaciones - revistas

<jats:title>How the immune system readies for battle</jats:title> <jats:p> Although gene expression is tightly controlled at both the RNA and protein levels, the quantitative contribution of each step, especially during dynamic responses, remains largely unknown. Indeed, there has been much debate whether changes in RNA level contribute substantially to protein-level regulation. Jovanovic <jats:italic>et al.</jats:italic> built a genome-scale model of the temporal dynamics of differential protein expression during the stimulation of immunological dendritic cells (see the Perspective by Li and Biggin). Newly stimulated functions involved the up-regulation of specific RNAs and concomitant increases in the levels of the proteins they encode, whereas housekeeping functions were regulated posttranscriptionally at the protein level. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1259038">10.1126/science.1259038</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1066" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa8332">1066</jats:related-article> </jats:p>

<jats:p>Scientists frequently lament the scarcity of effective scientific communicators—those who can explain complex concepts to the public, present scientifically sound alternatives to policy-makers, and make cogent arguments for the value of science to society. A few stellar programs are designed to select and train elite articulators, but some simple steps can improve the communication skills of all scientists. Most researchers learn how to talk about science at meetings. If scientists cannot explain their work clearly and succinctly to their peers, it is highly unlikely that they can explain it effectively to nonspecialists. I recently helped to judge student papers at a large scientific meeting, an experience that brought to my attention the importance of such communication early in one's career. I offer a few tips on how to make the most of this invaluable training.</jats:p>